Mental Disorders May Up Risk for Subsequent Medical Conditions
Median hazard ratio was 1.37 for link between mental disorder, medical condition in Danish cohort
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Sleep Disorders
Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM-878.
Recently, we identified a novel orexin 2 (OX ) receptor antagonist, SDM-878 (2-(3-(2-(1H-pyrazol-1-yl)nicotinoyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-3-methoxyisonicotinonitrile). The purpose of the present study is to...
Read MoreVarious Aspects of Tiagabine Effectiveness as Add-on Therapy in Patients with Refractory Epilepsy.
The aim of the present study was to investigate various aspects of tiagabine (TGB) effectiveness in Bulgarian patients with drug-resistant epilepsy. This open, prospective study recruited the patients with epilepsy attending the...
Read MoreAutomated phase classification in cyclic alternating patterns in sleep stages using Wigner-Ville Distribution based features.
Sleep is one of the most important body mechanisms responsible for the proper functioning of human body. Cyclic alternating patterns (CAP) play an indispensable role in the analysis of sleep quality and related disorders like...
Read MoreBlackout of my nights: Contentless, timeless and selfless report from the night in patients with central hypersomnias.
At the extreme spectrum of consciousness during sleep, some patients with rare hypersomnias reported experiencing a specific night ‘blackout’ when sleeping, i.e., an absence of experiences or recall of them from...
Read MoreSuicidal ideation and suicide attempts: associations with sleep duration, insomnia, and inflammation.
Sleep disturbance has been consistently identified as an independent contributor to suicide risk. Inflammation has emerged as a potential mechanism linked to both sleep disturbance and suicide risk. This study tested...
Read MoreSleep disturbance mediates the link between childhood trauma and clinical outcome in severe mental disorders.
The experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the relationship between childhood...
Read MoreAutism Spectrum Disorder and Narcolepsy: A Possible Connection That Deserves to Be Investigated.
Narcolepsy in childhood-adolescence is characterized by a high occurrence of psychiatric comorbidities. The most frequent psychiatric disorders reported in these patients are attention deficit/hyperactivity disorder, depression,...
Read MoreThe epidemiology of regular opioid use and its association with mortality: Prospective cohort study of 466 486 UK biobank participants.
Opioids have, at most, small benefits for non-cancer pain in the medium and long-term but there is good evidence that they cause harm. The current study describes the characteristics and clinical status of people taking regular...
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