Factors associated with pulmonary impairment in HIV-infected South African adults.

PloS one 2017 09 1312(9) e0184530 doi 10.1371/journal.pone.0184530 Abstract BACKGROUND HIV-infected individuals have increased risk of developing obstructive lung disease (OLD). Studies from developed countries report high

A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.

Science signaling 2017 09 1210(496) pii 10.1126/scisignal.aal0180 Abstract GPR15 is an orphan G protein-coupled receptor (GPCR) that is found in lymphocytes. It functions as a co-receptor of

Colworth prize lecture 2016: exploiting new biological targets from a whole-cell phenotypic screening campaign for TB drug discovery.

Microbiology (Reading, England) 2017 09 12() doi 10.1099/mic.0.000522 Abstract Mycobacterium tuberculosis is the aetiological agent of tuberculosis (TB) and is the leading bacterial cause of mortality and

Killed whole-HIV vaccine; employing a well established strategy for antiviral vaccines.

AIDS research and therapy 2017 09 1214(1) 47 doi 10.1186/s12981-017-0176-5 Abstract The development of an efficient prophylactic HIV vaccine has been one of the major challenges in

Normal intrathecal leukocyte cell number and composition do not decrease the incidence of post-lumbar puncture headache.

Journal of neuroimmunology 2017 06 30310() 69-71 pii 10.1016/j.jneuroim.2017.06.011 Abstract The pathogenesis of post-lumbar puncture headache (PLPH) has remained unclear. A beneficial role of CSF cells in

Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus.

Journal of virology 2017 09 1291(19) pii 10.1128/JVI.00505-17 Abstract The switch of Kaposi’s sarcoma-associated herpesvirus (KSHV) from latency to lytic replication is a key event for viral

Neurosyphilis Increases Human Immunodeficiency Virus (HIV)-associated Central Nervous System Inflammation but Does Not Explain Cognitive Impairment in HIV-infected Individuals With Syphilis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 65(6) 943-948 doi 10.1093/cid/cix473 Abstract Background Individuals infected with human immunodeficiency virus (HIV)

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.

PLoS pathogens 2017 09 1313(9) e1006614 doi 10.1371/journal.ppat.1006614 Abstract Extensive shielding by N-glycans on the surface of the HIV envelope glycoproteins (Env) restricts B cell recognition of

HIV seroconversion among Baltimore City residents tested at a mobile van programme.

Sexually transmitted infections 2017 09 12() pii 10.1136/sextrans-2017-053104 Abstract BACKGROUND Many individuals with HIV in the USA are unaware of their diagnosis, and therefore cannot be engaged

Preventing HIV infection without targeting the virus: how reducing HIV target cells at the genital tract is a new approach to HIV prevention.

AIDS research and therapy 2017 09 1214(1) 46 doi 10.1186/s12981-017-0166-7 Abstract For over three decades, HIV infection has had a tremendous impact on the lives of individuals

A novel HIV vaccine targeting the protease cleavage sites.

AIDS research and therapy 2017 09 1214(1) 51 doi 10.1186/s12981-017-0174-7 Abstract HIV preferentially infects activated CD4+ T cells and mutates rapidly. The classical vaccine approach aimed to

Characterization of naïve, memory and effector T cells in progressive multiple sclerosis.

Journal of neuroimmunology 2017 06 03310() 17-25 pii 10.1016/j.jneuroim.2017.06.001 Abstract We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4(+) and

Preferential Targeting of Conserved Gag Regions after Vaccination with a Heterologous DNA Prime-Modified Vaccinia Virus Ankara Boost HIV-1 Vaccine Regimen.

Journal of virology 2017 08 2491(18) pii 10.1128/JVI.00730-17 Abstract Prime-boost vaccination strategies against HIV-1 often include multiple variants for a given immunogen for better coverage of the

Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques.

Journal of virology 2017 09 1291(19) pii 10.1128/JVI.00401-17 Abstract Evaluation of the epitope specificities, locations (systemic or mucosal), and effector functions of antibodies elicited by novel HIV-1

PCR detection of human herpesviruses in colonic mucosa of individuals with inflammatory bowel disease: Comparison with individuals with immunocompetency and HIV infection.

PloS one 2017 09 1312(9) e0184699 doi 10.1371/journal.pone.0184699 Abstract BACKGROUND Detection of human herpesviruses (HHVs) other than cytomegalovirus (CMV) in colonic mucosa of individuals with inflammatory bowel

Novel endogenous retrovirus-derived transcript expressed in the bovine placenta is regulated by WNT signaling.

The Biochemical journal 2017 09 12() pii 10.1042/BCJ20170531 Abstract Endogenous retroviruses (ERVs) are involved in placentation; perhaps the most well-known ERV s are the syncytins, actively transcribed

HIV-I Nef inhibitors: a novel class of HIV-specific immune adjuvants in support of a cure.

AIDS research and therapy 2017 09 1214(1) 53 doi 10.1186/s12981-017-0175-6 Abstract The success of many current vaccines relies on a formulation that incorporates an immune activating adjuvant.

Hepatoprotective effects of Yulangsan flavone against carbon tetrachloride (CCl4)-induced hepatic fibrosis in rats.

Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 07 1133() 28-35 pii 10.1016/j.phymed.2017.07.005 Abstract BACKGROUND Yulangsan flavone (YLSF) was extracted from the root of Millettia pulchra

HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis-Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection.

Journal of immunology (Baltimore, Md. : 1950) 2017 07 31199(6) 2069-2080 doi 10.4049/jimmunol.1700558 Abstract Coinfection with HIV is the single greatest risk factor for reactivation of latent

HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV.

Journal of virology 2017 08 2491(18) pii 10.1128/JVI.00700-17 Abstract Studying HIV-infected individuals who control HIV replication (elite controllers [ECs]) enables exploration of effective anti-HIV immunity. HIV Env-specific

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