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Oncology

Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing.

Neoplasia (New York, N.Y.) 2018 02 1320(3) 256-262 pii 10.1016/j.neo.2017.12.005 Abstract The tumor suppressor gene TP53 is the most frequently mutated gene in human cancer. It encodes

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

Molecular cell 69(4) 566-580.e5 pii 10.1016/j.molcel.2018.01.027 Abstract Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor κB (NF-κB)-dependent checkpoints

Detection of Crohn Disease in Patients with Spondyloarthropathy: The SpACE Capsule Study.

The Journal of rheumatology 2018 02 15() pii 10.3899/jrheum.161216 Abstract OBJECTIVE Inflammatory bowel disease (IBD) is generally reported to be associated with spondylarthropathies (SpA) in 5%-15% of

Recombinant FXIII (rFXIII-A2) Prophylaxis Prevents Bleeding and Allows for Surgery in Patients with Congenital FXIII A-Subunit Deficiency.

Thrombosis and haemostasis 2018 02 15() doi 10.1055/s-0038-1624581 Abstract Recombinant factor XIII-A(rFXIII-A) was developed for prophylaxis and treatment of bleeds in patients with congenital FXIII A-subunit deficiency.

Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.

PLoS genetics 2018 02 1514(2) e1007225 doi 10.1371/journal.pgen.1007225 Abstract The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell

Lung Function, Inflammation, and Endothelin-1 in Congenital Heart Disease-Associated Pulmonary Arterial Hypertension.

Journal of the American Heart Association 2018 02 147(4) pii 10.1161/JAHA.117.007249 Abstract BACKGROUND Breathlessness is the most common symptom in people with pulmonary arterial hypertension and congenital

Synergistic activity of BET inhibitor BI 894999 with PLK inhibitor volasertib in AML in vitro and in vivo.

Cancer letters 2018 02 14() pii 10.1016/j.canlet.2018.02.018 Abstract Interactions between a new potent Bromodomain and extraterminal domain (BET) inhibitor BI 894999 and the polo-like kinase (PLK) inhibitor

Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study.

Cardiovascular diabetology 2018 02 1617(1) 28 doi 10.1186/s12933-018-0670-7 Abstract BACKGROUND No study evaluated vascular health markers in subjects with non-alcoholic fatty liver disease (NAFLD) through a combined

Mixed-species RNAseq analysis of human lymphoma cells adhering to mouse stromal cells identifies a core gene set that is also differentially expressed in the lymph node microenvironment of mantle cell lymphoma and chronic lymphocytic leukemia patients.

Haematologica 2018 02 15() pii 10.3324/haematol.2017.182048 Abstract A subset of hematological cancer patients is refractory to treatment or suffers relapse, due in part to minimal residual disease,

Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model.

Aging 2018 02 15() doi 10.18632/aging.101387 Abstract Circular RNAs (circRNAs), a novel kind of non-coding RNA, have received increasing attention for their involvement in pathogenesis of Alzheimer’s

Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study.

PLoS genetics 2018 02 1514(2) e1007194 doi 10.1371/journal.pgen.1007194 Abstract Given prior evidence that an affected woman conveys a higher risk of ovarian cancer to her sister than

Monitoring of mechanical errors and their dosimetric impact throughout the course of non-coplanar continuous volumetric-modulated arc therapy.

Radiation oncology (London, England) 2018 02 1413(1) 27 doi 10.1186/s13014-018-0972-7 Abstract BACKGROUND Volumetric-modulated Dynamic WaveArc therapy (VMDWAT) is a non-coplanar continuous volumetric modulated radiation therapy (VMAT) delivery

Ketamine induces apoptosis in lung adenocarcinoma cells by regulating the expression of CD69.

Cancer medicine 2018 02 17() doi 10.1002/cam4.1288 Abstract Ketamine, an anesthetic, analgesic, or sedative, is widely used for the treatment of cancer pain. Recently, ketamine has been

Patterns of paediatric end-of-life care: a chart review across different care settings in Switzerland.

BMC pediatrics 2018 02 1618(1) 67 doi 10.1186/s12887-018-1021-2 Abstract BACKGROUND Paediatric end-of-life care is challenging and requires a high level of professional expertise. It is important that

MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia.

Haematologica 2018 02 15() pii 10.3324/haematol.2017.176362 Abstract Survival of children with relapsed acute lymphoblastic leukemia is poor and understanding mechanisms underlying resistance is essential in developing new

The Correlation Between Serum Chemokines and Clinical Outcome in Patients with Advanced Biliary Tract Cancer.

Translational oncology 2018 02 1211(2) 353-357 pii 10.1016/j.tranon.2018.01.007 Abstract BACKGROUND Biliary tract cancers (BTCs) are known to have a dismal prognosis. A number of chemokines play important

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade.

The Journal of clinical investigation 2018 02 15() doi 10.1172/JCI90277 Abstract Synthetic lethality is an efficient mechanism-based approach to selectively target DNA repair defects. ERCC1 deficiency is

Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density.

Breast cancer research : BCR 2018 02 1420(1) 14 doi 10.1186/s13058-018-0940-z Abstract BACKGROUND Mammographic breast density is one of the strongest risk factors for breast cancer, but

IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells.

Scientific reports 2018 02 168(1) 3217 doi 10.1038/s41598-018-21344-7 Abstract Successful replication of Human immunodeficiency virus (HIV)-1 depends on the expression of various cellular host factors, such as

Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment.

PloS one 2018 02 1613(2) e0193048 doi 10.1371/journal.pone.0193048 Abstract Despite of multitude investigations no reliable prognostic immunohistochemical biomarkers in GIST have been established so far with added

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