Asthma

Most asthma patients can be easily controlled with a typical mix of inhaled controllers and relief medications, but there is still a significant unmet demand at the severe end of the illness...

Jan 06, 2022

Orai1 is a Ca2+ channel in a murine allergic asthma model in the plasma membrane that regulates inflammation and mediates store-operated Ca2+ entry (SOCE). SPLUNC1 (short palate lung and nas...

Jan 03, 2022

Although allergic asthma is a common chronic inflammatory illness, the underlying pathophysiology that causes Th2 type inflammation remains unknown. Although Wnt/-catenin signaling has been ...

Dec 27, 2021

Asthma is a chronic lung disease, which causes wheezing, tightness in the chest, shortness of breath and coughing. In the wake of coronavirus disease 2019 (COVID-19), which affect the lungs,...

Dec 27, 2021

Epigenetic processes such as DNA methylation, histone modification, and microRNA regulate genome accessibility and govern gene transcription in a heritable manner in response to environmenta...

Dec 20, 2021

A phase III clinical study was done in a population greater than or equal to 2 years to assess the safety and immunogenicity of a novel 23-valent pneumococcal polysaccharide vaccine (PPV23)....

Dec 17, 2021

Evidence suggests that well-known mast cell mediators, such as histamine and bioactive lipids, are responsible for many of the physiological effects observed in the acute phase of allergic r...

Oct 26, 2021

Childhood-onset asthma is associated with the most independent loci compared with other defined groups of asthma and allergic disease cases, according to a review published in The Journal of...

Oct 26, 2021

The underlying chronic inflammatory process and airway remodeling (AR) that occur in asthma contribute to the symptomatology of the disease. Today, the most severely ill asthma patients can ...

Oct 26, 2021

A systematic review of 24 real-world observational studies in adult patients with severe allergic asthma (SAA) has confirmed the short- and long-term efficacy of omalizumab in improving lung...

Oct 26, 2021

Exacerbation rates and forced expiration volume (FEV1) improvements with omalizumab treatment were similar irrespective of comorbidity burden, according to a study published in Annals of All...

Oct 26, 2021

The anti-immunoglobulin (IgE) monoclonal antibody omalizumab proved beneficial for all patients with severe allergic asthma (SAA) and especially for patients with multiple allergic comorbidi...

Oct 25, 2021

The data on biological therapies on Airway remodeling (AR) in severe asthma require further studies. The American Thoracic Society recommends future research focus on AR in asthma and improv...

Oct 05, 2021

Clinical trials and observational studies have demonstrated that omalizumab is safe and effective for treating pediatric asthma. However, further research must be conducted to determine the ...

Oct 05, 2021

This review summarizes research on mast cells, and the implications of the role and development of mast cells in allergic asthma. The study focuses on the progenitors of mast cells in allerg...

Oct 05, 2021

With monoclonal antibodies being a relatively new therapy option for patients with severe chronic airway diseases, asthma, allergic rhinitis, and chronic rhinosinusitis (CRS), researchers co...

Oct 05, 2021

Although data support the successful use of omalizumab as a supplementary therapy to improve asthma control in children older than 6 with moderate or severe persistent allergic asthma, the e...

Oct 05, 2021

Larger studies are needed focusing on genome-wide association studies (GWASs) of asthma and allergic diseases, especially in the patients with childhood-onset asthma and allergic diseases gr...

Oct 05, 2021

This study found there was high certainty for patients with asthma between 6-12 years old that used omalizumab to experience decreased annual exacerbation rate, improved quality of life (QoL...

Oct 05, 2021

“Consistent improvements in Global evaluation of treatment effectiveness (GETE), lung function, and patient-reported outcomes (PROs), and reductions in asthma exacerbations, oral corticost...

Oct 05, 2021