The goal of this study is to present the utility of quantitative modeling for extrapolation of drug safety and efficacy to underrepresented populations in controlled clinical trials. To illu...
Secondary pulmonary hypertension (PH) is a serious complication of end-stage lung disease and is associated with unfavorable prognosis. The aim of the study was to evaluate the incidence and...
Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, muc...
Pseudomonas aeruginosa is a priority pathogen for the development of new antibiotics, particularly because multi-drug resistant strains of this bacterium cause serious nosocomial infections ...
Mycobacterium abscessus is an emerging multidrug-resistant bacterial pathogen causing severe lung infections in cystic fibrosis patients. A remarkable trait of this mycobacterial species is ...
There is an urgent need for new antimicrobials to treat the opportunistic Gram-negative , which represents a problematic challenge for cystic fibrosis patients. Recently, a benzothiadiazole ...
In response to recurrent infection in cystic fibrosis (CF), powerful innate immune signals trigger polymorphonuclear neutrophil recruitment into the airway lumen. Exaggerated neutrophil prot...
High-frequency chest wall oscillation (HFCWO) is a commonly prescribed airway clearance technique (ACT) for patients whose ability to expectorate sputum is compromised. This study aimed to a...
In contrast to pain processing neurons in the spinal cord, where the importance of chloride conductances is already well established, chloride homeostasis in primary afferent neurons has rec...
TMEM16A is a Ca activated Cl channel with important functions in airways, intestine, and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (CF) to re...
Mechanisms that facilitate early infection and inflammation in cystic fibrosis (CF) are unclear. We previously showed that young CF children with secondhand smoke exposure (SHSe) have increa...
Stenotrophomonas maltophilia is a bacteria whose role in patients with cystic fibrosis bronchiectasis has been previously studied; little is known about its role in non-CF bronchiectasis.Inv...
Studies suggest that a diet rich in omega-3 essential fatty acids may have beneficial anti-inflammatory effects for chronic conditions such as cystic fibrosis. This is an updated version of ...
Discovery of the cystic fibrosis transmembrane conductance regulator ( gene was the long-awaited scientific advance that dramatically improved the diagnosis and treatment of cystic fibrosis ...
International panel does quick turnaround McMaster University Hamilton, ON (April 1, 2020) - An international team including McMaster University researchers has come together to issue guid...
While lung transplantation (LTx) improves health-related quality of life (HRQL) in cystic fibrosis (CF), the determinants of this improvement are unknown. In other populations, frailty-a syn...
Chronic infection and concomitant airway inflammation is the leading cause of morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in CF is undenia...
Chronic pulmonary infection is a hallmark of lung disease in cystic fibrosis. Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related sp...
We investigated the regulation of Cl secretion by adrenoceptors in polarized 16HBE14o- human bronchial epithelial cells. Treatment with the nonselective β adrenoceptor agonist isoprenaline ...
Increased lung recruitability seen with alternating body position between supine and prone positioning (HealthDay News) -- Lung recruitability can be assessed at bedside in mechanically...
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