Study Connects the Dots Between Smoking and Stroke Risk in African Americans
Risk increases as more cigarettes are smoked According to the Office of Minority Health of the...
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Lung Cancer
ASCO: Gastric Cancer Patients Respond to Trastuzumab Deruxtecan
Overall survival also extended with conjugate treatment In a small, phase II trial, patients with advanced gastric cancer were far more likely to respond to conjugate therapy with trastuzumab deruxtecan (Enhertu) than with...
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Conference Highlights: AATS 2020
New research was presented at AATS 2020, the virtual Annual Meeting of the American Association...
Read MoreTherapeutic options for advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer: a Bayesian network secondary analysis.
The most favorable treatments for advanced EGFR-mutant NSCLC are less indicated. Forty-one studies were eligible for this Bayesian network secondary analysis. For PFS, erlotinib (Erlo)+bevacizumab (Bev) (HR 0.26, 95% CrI:...
Read MoreAOC4P suppresses viability and invasion and induces apoptosis in NSCLC cells by inhibiting the Wnt/β-catenin pathway.
Increasing studies have well-documented the involvement of numerous lncRNAs in regulating the malignant phenotypes of various tumors including non-small cell lung cancer (NSCLC) cells. However, up to date, the effects and...
Read MoreCell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
Cell adhesion molecule 4 (CADM4) is downregulated in many human cancers. However, CADM4 expression levels in human non-small cell lung cancer (NSCLC) tissues and its roles in NSCLC progression remain unknown. Our study aims to...
Read MoreAn immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer.
Dissemination of non-small-cell lung cancer (NSCLC) in the central nervous system is a frequent and challenging clinical problem. Systemic or local therapies rarely prolong survival and have modest activity regarding local...
Read MoreIn vitro anticancer effects of levopimaric acid in cisplatin-resistant human lung carcinoma are mediated via autophagy, ROS-mediated mitochondrial dysfunction, cell apoptosis and modulation of ERK/MAPK/JNK signalling pathway.
Lung cancer is one of the deadly diseases with limited treatment options available. The main aim of the current study was to investigate the antitumor effects of levopimaric acid – a naturally occurring diterpene, against...
Read MoreAntitumor effects of flavokawain-B flavonoid in gemcitabine-resistant lung cancer cells are mediated via mitochondrial-mediated apoptosis, ROS production, cell migration and cell invasion inhibition and blocking of PI3K/AKT Signaling pathway.
Drug resistance in lung cancer is a growing and challenging problem affecting the overall treatment and quality of the patient’s life. The main purpose of the current study was to investigate the anticancer effects of...
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