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Lung Cancer

ASCO: Gastric Cancer Patients Respond to Trastuzumab Deruxtecan

Jun 02, 2020

Overall survival also extended with conjugate treatment In a small, phase II trial, patients with advanced gastric cancer were far more likely to respond to conjugate therapy with trastuzumab deruxte...

Conference Highlights: AATS 2020

May 27, 2020

New research was presented at AATS 2020, the virtual Annual Meeting of the American Association for Thoracic Surgery, from May 22-23. The features below highlight some of the studies presented via the...

Therapeutic options for advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer: a Bayesian network secondary analysis.

Apr 24, 2020

The most favorable treatments for advanced EGFR-mutant NSCLC are less indicated. Forty-one studies were eligible for this Bayesian network secondary analysis. For PFS, erlotinib (Erlo)+bevacizumab (Be...

AOC4P suppresses viability and invasion and induces apoptosis in NSCLC cells by inhibiting the Wnt/β-catenin pathway.

Apr 24, 2020

Increasing studies have well-documented the involvement of numerous lncRNAs in regulating the malignant phenotypes of various tumors including non-small cell lung cancer (NSCLC) cells. However, up to ...

Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.

Apr 24, 2020

Cell adhesion molecule 4 (CADM4) is downregulated in many human cancers. However, CADM4 expression levels in human non-small cell lung cancer (NSCLC) tissues and its roles in NSCLC progression remain ...

An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer.

Apr 24, 2020

Dissemination of non-small-cell lung cancer (NSCLC) in the central nervous system is a frequent and challenging clinical problem. Systemic or local therapies rarely prolong survival and have modest a...

In vitro anticancer effects of levopimaric acid in cisplatin-resistant human lung carcinoma are mediated via autophagy, ROS-mediated mitochondrial dysfunction, cell apoptosis and modulation of ERK/MAPK/JNK signalling pathway.

Apr 12, 2020

Lung cancer is one of the deadly diseases with limited treatment options available. The main aim of the current study was to investigate the antitumor effects of levopimaric acid - a naturally occurri...

Antitumor effects of flavokawain-B flavonoid in gemcitabine-resistant lung cancer cells are mediated via mitochondrial-mediated apoptosis, ROS production, cell migration and cell invasion inhibition and blocking of PI3K/AKT Signaling pathway.

Apr 12, 2020

Drug resistance in lung cancer is a growing and challenging problem affecting the overall treatment and quality of the patient's life. The main purpose of the current study was to investigate the anti...

The effect of PD-L1 status on survival outcomes in patients with stage II-III non-small cell lung cancer treated with chemotherapy.

Apr 12, 2020

There are conflicting results in the literature about the relationship between PD-1/PD-L1 expression and prognosis in non-small cell lung cancer (NSCLC). The purpose of this study was to identify the ...

ERCC2 Lys751Gln rs13181 and XRCC2 Arg188His rs3218536 Gene Polymorphisms Contribute to Subsceptibility of Colon, Gastric, HCC, Lung And Prostate Cancer.

Apr 12, 2020

Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. The relationship between genetic polymorphisms and cancer risk h...

Lung Cancer Inhibition by Betulinic Acid Nanoparticles via Adenosine 5'-Triphosphate (ATP)-Binding Cassette Transporter G1 Gene Downregulation.

Apr 12, 2020

BACKGROUND Despite scientific advancement in radiotherapy and chemotherapy, the 5-year survival rate of lung cancer patients is around 15%. The present study explored the anticancer potential of betul...

New guidelines on caring for ICU patients with COVID-19

Apr 07, 2020

International panel does quick turnaround McMaster University Hamilton, ON (April 1, 2020) - An international team including McMaster University researchers has come together to issue guidelines for...

Robotic Approach Offers Similar Nodal Upstaging to Open Lobectomy for Clinical Stage I NSCLC.

Apr 03, 2020

Appropriate nodal dissection during pulmonary resection improves pathologic staging accuracy. Detection of unexpected nodal metastases can be a surrogate for nodal dissection adequacy and reflect onco...

Proteomics analysis of tumor exosomes reveals vital pathways of Jinfukang inhibiting circulating tumor cells metastasis in lung cancer.

Apr 03, 2020

Jinfukang has long been used for the clinical treatment of lung cancer. Previous studies have shown that Jinfukang can induce the apoptosis of circulating tumor cells by intervening ROS-mediated DNA d...

Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer: clinical and biomarker results from a Phase I trial.

Apr 03, 2020

Dysregulation of receptor tyrosine kinase MET by various mechanisms occurs in 3-4% of NSCLC and is associated with unfavorable prognosis. While MET is a validated drug target in lung cancer the best b...

Exercise-Mediated Lowering of Glutamine Availability Suppresses Tumor Growth and Attenuates Muscle Wasting.

Apr 03, 2020

Glutamine is a central nutrient for many cancers, contributing to the generation of building blocks and energy-promoting signaling necessary for neoplastic proliferation. In this study, we hypothesize...

The clinicopathological and prognostic value of the pretreatment neutrophil-to-lymphocyte ratio in small cell lung cancer: A meta-analysis.

Apr 03, 2020

Although many scholars have recently studied the relationships between the pretreatment neutrophil-to-lymphocyte ratio (NLR) and prognosis in patients with small cell lung cancer (SCLC), the conclusio...

Vitamin C May Reduce Ventilation Time in Critically Ill Patients

Mar 29, 2020

Review shows vitamin C can shorten the duration of mechanical ventilation by an average of 25 percent The administration of vitamin C shortens the length of mechanical ventilation in critically i...

FDA Warns of Defective EpiPen Dangers

Mar 25, 2020

WEDNESDAY, March 25, 2020 (HealthDay News) -- Certain types of EpiPens and their generic counterparts may fail or delay injection of lifesaving epinephrine for severe allergic reactions, the U.S. Food...

Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study.

Mar 24, 2020

Reproductive factors and hormone use in postmenopausal women have been hypothesised to affect the risk of developing lung cancer, but the epidemiological evidence is inconsistent.Using the Korean Nat...