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Lung Cancer

Constructing E-Nose Using Metal-Ion Induced Assembly of Graphene Oxide for Diagnosis of Lung Cancer via Exhaled Breath.

Mar 24, 2020

Flexible electronic-nose (E-nose) was constructed by assembling graphene oxide (GO) using different types of metal-ions (Mx+) with different ratio of GO to Mx+. Owing to the crosslinked networks, the ...

Efficacy of immune check-point inhibitors (ICPi) in large cell neuroendocrine tumors of lung (LCNEC).

Mar 24, 2020

Little is known regarding the ICPi efficacy in LCNEC. We explored the efficacy and safety of ICPi in LCNEC and assessed its impact on OS.Thirty-seven consecutive patients with advanced LCNEC were sele...

Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer.

Mar 24, 2020

Conventional evaluation of anti-tumor activity on the basis of tumor size is inadequate for immune checkpoint inhibitors (ICIs). We therefore aimed to assess the usefulness of intravoxel incoherent mo...

Impact of Age on Inflammation-Based Scores among Patients Diagnosed with Stage III Non-Small Cell Lung Cancer.

Mar 24, 2020

Inflammatory and nutritional indexes are prognostic factors in non-small cell lung cancer (NSCLC). Furthermore, a low grade of chronic inflammation has been described in the older population (inflamma...

Statement Addresses Concerns About Heart Meds and COVID-19

Mar 22, 2020

Patients advised to continue ACE inhibitors/ARBs after researcher posits risk for severe COVID-19 infection FRIDAY, March 20, 2020 (HealthDay News) -- Patients already prescribed angiotensin-conv...

Digestive Symptoms Reported for About Half of COVID-19 Patients

Mar 19, 2020

THURSDAY, March 19, 2020 (HealthDay News) -- Patients with coronavirus 2019 (COVID-19) frequently have digestive symptoms, and those with digestive symptoms have a worse clinical outcome, according to...

ALK and ROS1 rearrangement tested by ARMS-PCR in non-small-cell lung cancer patients via cytology specimens: The experience of Shanghai Pulmonary Hospital.

Mar 10, 2020

Cytology specimens are the main samples used for the diagnosis of advanced lung cancer. The objective of our study was to assess anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 receptor tyrosine...

Variants in Epithelial-Mesenchymal Transition and Immune Checkpoint Genes Are Associated With Immune Cell Profiles and Predict Survival in Non-Small Cell Lung Cancer.

Mar 10, 2020

Identification of gene mutations that are indicative of epithelial-mesenchymal transition and a noninflammatory immune phenotype may be important for predicting response to immune checkpoint inhibitor...

Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non-Small-Cell Lung Cancer.

Mar 10, 2020

In KEYNOTE-189, first-line pembrolizumab plus pemetrexed-platinum significantly improved overall survival (OS) and progression-free survival (PFS) compared with placebo plus pemetrexed-platinum in pat...

Prognostic significance of the radiologic features of pneumonitis induced by anti-PD-1 therapy.

Mar 10, 2020

Interstitial lung disease (ILD) induced by anti-programmed-cell death-1 (PD-1) and anti-PD-ligand 1 (PD-L1) is potentially life-threatening and is a common reason of the discontinuation of therapy. In...

Identification of Potential Diagnostic and Prognostic Values of Expression in Lung Cancer, Breast Cancer, and Head and Neck Cancer.

Mar 10, 2020

The aims of this study were to investigate the expression of prolyl 4-hydroxylase subunit alpha-1 (P4HA1) and its relationship with clinicopathological features in lung cancer (LC), breast cancer (BC)...

Lumbar Puncture Guidance

Mar 09, 2020

Data indicate that nearly 400,000 lumbar punctures (LPs) are performed annually for either diagnostic workup or therapeutic relief in the United States. Regular referral to radiology for assistance ...

Smoking cessation programmes for women living in disadvantaged communities, "We Can Quit 2": A systematic review protocol.

Feb 28, 2020

Tobacco use is the leading cause of preventable death in Ireland with almost 6,000 smokers dying each year from smoking-related diseases. Amongst younger Irish women, smoking rates are considerably hi...

Paclitaxel-in-liposome-in-bacteria for inhalation treatment of primary lung cancer.

Feb 28, 2020

Bacterial therapy is emerging for the treatment of cancers though some scientific and clinical problems have not been addressed. Here, a living drug-loaded carrier, paclitaxel-in-liposome-in-bacteria ...

Clinical outcomes of stereotactic MR-guided adaptive radiation therapy for high-risk lung tumors.

Feb 28, 2020

Magnetic resonance (MR-)guided stereotactic ablative radiotherapy (SABR) was performed for patients with lung tumors in whom treatment delivery was challenging due to tumor location, motion or pulmona...

Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells.

Feb 28, 2020

Human Ly-6/uPAR-related protein-1 (SLURP-1) is an allosteric negative modulator of the α7-type nicotinic acetylcholine receptor (α7-nAChR), one of the key receptors promoting nicotine-induced prolif...

Managing Hyperprogressive Disease in the Era of Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Blockade: A Case Discussion and Review of the Literature.

Feb 25, 2020

A breakthrough in oncology over the last 5 years, immunotherapy has proved its salutary effects in a wide range of solid tumors. The targeting of the programmed cell death protein 1 (PD-1)/programme...

Clinicopathological significance of microRNA-21 in extracellular vesicles of pleural lavage fluid of lung adenocarcinoma and its functions inducing the mesothelial to mesenchymal transition.

Feb 25, 2020

Pre-resection pleural lavage cytology is useful to predict tumor recurrence and the prognosis of lung cancer patients. Recently, extracellular vesicles (EVs) isolated from effusion specimens have come...

Automatic lung nodule detection combined with gaze information improves radiologists' screening performance.

Feb 25, 2020

Early diagnosis of lung cancer via computed tomography can significantly reduce the morbidity and mortality rates associated with the pathology. However, search lung nodules is a high complexity task,...

High Expression of Krüppel-like Factor 7 Indicates Unfavorable Clinical Outcomes in Patients with Lung Adenocarcinoma.

Feb 25, 2020

Krüppel-like factor 7 (KLF7), which belongs to the KLF family of zinc finger transcription factors, plays a critical role in regulating gene expression. It was reported that KLF7 overexpression was c...