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Lupus

Unmet Therapeutic Needs Observed for Patients With Lupus

Jun 16, 2022

Unmet therapeutic needs in patients with systemic lupus erythematosus is a widespread and serious issue that urgently needs to be addressed Understanding whether patients with systemic lupus er...

Conference Highlights: EULAR 2022

Jun 07, 2022

New research was presented at EULAR 2022, the European Alliance for Associations for Rheumatology Annual Meeting, from June 1-4 in Copenhagen, Denmark, and virtually. The features below highlight some...

Mannose Binding Lectin Levels and its Association with Systemic Lupus Erythematosus Disease Severity: An Indian Report.

May 23, 2022

Dysregulated serum levels of Mannan binding lectin (MBL) has a probable role in Systemic Lupus Erythematosus (SLE) pathogenesis.To evaluate the association between serum MBL levels in SLE patients fro...

Increased frequency of activated regulatory T cells in patients with lupus nephritis.

May 16, 2022

Lupus nephritis (LN) is one of the common manifestations of SLE, which affects the quality of life of patients. Abnormality in the adaptive immune response, such as T cell response, plays the main rol...

Mobile health apps for systemic lupus erythematosus and lupus nephritis: a critical appraisal.

May 16, 2022

To critically assess the quality and functionality of the available mobile apps for systemic lupus erythematosus and lupus nephritis patients.Two reviewers independently searched the App Store and Goo...

Melatonin alleviates the immune response and improves salivary gland function in primary Sjögren's syndrome.

May 09, 2022

Primary Sjögren's syndrome (pSS) is an autoimmune disease that primarily affects exocrine glands and is characterized by sicca syndrome and systemic manifestation. Mounting evidence indicates that ci...

The dynamics of Th17 / Treg ratio in SLE patients during pregnancy.

Apr 25, 2022

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder that affects women at childbearing age. During pregnancy, maternal immune system is challenged to tolerate a semi-allogenic fe...

Validating a Computable Phenotype for Nephrotic Syndrome in Children and Adults Using PCORnet Data.

Apr 18, 2022

Primary nephrotic syndromes are rare diseases which can impede adequate sample size for observational patient-oriented research and clinical trial enrollment. A computable phenotype may be powerful in...

Enrichment of complement, immunoglobulins and autoantibody targets in the proteome of platelets from patients with Systemic Lupus Erythematosus (SLE).

Apr 18, 2022

Background SLE is a complex disease characterized by autoimmunity towards apoptotic cells, excessive amounts of circulating immune complexes and complement activation. Decreased platelet size has been...

Multidisciplinary Lupus Nephritis Clinic Reduces Time to Renal Biopsy and Improves Care Quality.

Apr 11, 2022

Patients with lupus nephritis (LN) have a 26-fold higher mortality rate compared with their peers. Kidney biopsy, the gold standard diagnostic method for LN, may have an average wait time of more than...

Lupus nephritis diagnosis using enhanced moth flame algorithm with support vector machines.

Apr 11, 2022

Systemic lupus erythematosus is a chronic autoimmune disease that affects the kidney in most patients. Lupus nephritis (LN) is divided into six categories by the International Society of Nephrology/Re...

HMGB1 is increased in patients with immune thrombocytopenia and negatively associates with Tregs.

Apr 04, 2022

Refractory or recurrent immune thrombocytopenia (ITP) patients suffer from the dual threat of high mortality and drug toxicity in addition to a very poor quality of life. Previous studies have shown t...

Anifrolumab efficacy and safety by type I interferon gene signature and clinical subgroups in patients with SLE: post hoc analysis of pooled data from two phase III trials.

Mar 28, 2022

To characterise the efficacy and safety of anifrolumab in patients with systemic lupus erythematosus (SLE) according to interferon gene signature (IFNGS), demographic and clinical subgroups.We perform...

Recurrent strokes and memory loss in a patient with triple-positive antiphospholipid antibody syndrome.

Mar 28, 2022

Antiphospholipid syndrome may cause recurrent thromboembolic events of the microvasculature, arteries and veins. It is also characterised by a range of neurological and psychiatric dysfunctions, as we...

Cardiovascular disease risk in antiphospholipid syndrome: Thrombo-inflammation and atherothrombosis.

Mar 07, 2022

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPL) (lupus anticoagulant, anticardiolipin antibodies and anti-beta2glycoprotein...

Therapeutic plasma exchange in a patient with acute motor axonal neuropathy subtype of Guillain-Barre syndrome and systemic lupus erythematosus.

Feb 28, 2022

A young female in her early 20s with a history of systemic lupus erythematosus presented to the emergency department due to 4 days of progressive bilateral extremity weakness and numbness. The patie...

Association of Osteopontin gene single nucleotide polymorphism with lupus nephritis.

Feb 28, 2022

To determine the association of single nucleotide polymorphism at 9250 C/T in exon 7 of the Osteopontin (OPN) gene among Egyptian patients with lupus nephritis (LN) and healthy controls and assess its...

The global burden of heterogeneity of lupus erythematosus interventional trials.

Feb 21, 2022

To explore bias in lupus erythematosus (LE) randomized clinical trials (RCTs) and to help the development of benchmarks for future trials and management. We searched systematically three databases and...

Fucosylation of anti-dsDNA IgG1 correlates with disease activity of treatment-naïve systemic lupus erythematosus patients.

Feb 21, 2022

Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease mediated by quantities of autoantibodies in which anti-double-stranded DNA (anti-dsDNA) antibodies are important. B...

Systemic lupus erythematosus with secondary thrombotic thrombocytopenic purpura and acute parkinsonism: A case report.

Feb 14, 2022

Systemic lupus erythematosus (SLE) is an autoimmune disease that has certain characteristic features but can also present with misleading signs and symptoms especially when it is of late-onset. Variou...