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Lupus

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Reflect Disease Activity and Flares in Patients with Systemic Lupus Erythematosus - a Prospective Study.

Jan 17, 2022

To determine the association between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with disease activity and flares in an inception cohort of patients with systemic lupus...

Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients.

Jan 17, 2022

Systemic lupus erythematosus (SLE) is characterized by expansion of autoreactive lymphocytes and impaired management of oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays a sig...

Gut dysbiosis is associated with acceleration of lupus nephritis.

Jan 10, 2022

The gut microbiota (GM) exerts a strong influence over the host immune system and dysbiosis of this microbial community can affect the clinical phenotype in chronic inflammatory conditions. To explore...

The effects of autoimmune rheumatic-related diseases on male reproductive health: A systematic review.

Jan 10, 2022

Autoimmune rheumatic-related diseases (ARRDs) have physical and psychological impact on patients, including their sexual life. While many studies have investigated fertility problems in females, data ...

Reduced expression of hematopoietic progenitor kinase 1 in T follicular helper cells causes autoimmunity of systemic lupus erythematosus.

Jan 03, 2022

T follicular helper (Tfh) cells have been discovered to be the main CD4 T cells assisting B cells to produce antibody. They are over activated in patients with systemic lupus erythematosus (SLE) and c...

An Epigenetics-Based Hypothesis of Autoantigen Development in Systemic Lupus Erythematosus.

Jan 03, 2022

Currently, we have a limited understanding of mechanisms leading to systemic lupus erythematosus, but we know that genetics, environmental factors, and epigenetics contribute to the disease. One commo...

Assessment of the Sources of Information by Patients With Rheumatic Diseases.

Dec 27, 2021

The aim of this study was to ascertain the frequency of use, search intent (SI), level of accessibility, and degree of reliability of sources of information (SOIs) in rheumatology.A survey among adult...

Long-Term Safety and Efficacy of Belimumab in Japanese Patients with SLE: a 7-Year Open-Label Continuation Study.

Dec 20, 2021

Evaluate long-term safety, tolerability and efficacy of belimumab in Japanese patients with systemic lupus erythematosus (SLE).This was a subgroup analysis of Japanese patients who completed studies B...

Efficacy and Safety of High-Dose of Mycophenolate Mofetil Compared With Cyclophosphamide Pulse Therapy as Induction Therapy in Japanese Patients with Proliferative Lupus Nephritis.

Dec 20, 2021

To clarify the effectiveness and safety of induction therapy with mycophenolate mofetil (MMF) in patients with lupus nephritis (LN).Patients with LN administered MMF (n = 35) or IVCY (n = 25) plus hig...

Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor.

Nov 29, 2021

We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later....

The Nature of Coxofemoral Joint Pathology Across Family Canidae.

Nov 29, 2021

We evaluated coxofemoral joints from museum specimens of: Vulpes lagopus; Vulpes vulpes; Vulpes velox; Nyctereutes procyonoides; Urocyon cinereoargenteus; Aenocyon [Canis] dirus; Canis latrans; Canis ...

Epstein-Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci.

Nov 22, 2021

The interplay between environmental and genetic factors plays a key role in the development of many autoimmune diseases. In particular, the Epstein-Barr virus (EBV) is an established contributor to mu...

Neurofilament light in plasma is a potential biomarker of central nervous system involvement in systemic lupus erythematosus.

Nov 22, 2021

Neuropsychiatric manifestations (NP) are common in systemic lupus erythematosus (SLE). However, the pathophysiological mechanisms are not completely understood. Neurofilament light protein (NfL) is pa...

Semiquantitative interpretation of anticardiolipin and antiβ2glycoprotein I antibodies measured with various analytical platforms: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies.

Nov 15, 2021

Antiβ2glycoprotein I (aβ2GPI) and anticardiolipin (aCL) IgG/IgM show differences in positive/negative agreement and titers between solid phase platforms. Method specific semiquantitative categorizat...

[Value of IgA antiphospholipid antibodies in diagnosis of the antiphospholipid syndrome].

Nov 15, 2021

To examine the prevalence of multiple antiphospholipid antibodies (aPL) subtypes in healthy people and antiphospholipid syndrome (APS) patients, and to assess the value of IgA-aPL in the diagnosis of...

Detection of Trypanosoma cruzi infection by PCR in Canis lupus familiaris and their ectoparasites in Chile.

Nov 01, 2021

Chronic Chagas disease affects humans and animals, involving rural and urban inhabitants. Dogs participate in the maintenance and transmission of Trypanosoma cruzi. The objective of this study was to ...

Kidney transplant outcomes in children and adolescents with systemic lupus erythematosus.

Oct 25, 2021

Literature supports equivalent kidney transplant outcomes in adults with systemic lupus erythematosus (SLE) compared with those without SLE. However, there are conflicting and scant data on kidney tra...

Catastrophic Antiphospholipid Syndrome Associated With Systemic Lupus Erythematosus Flare With Multiorgan Failure: A Chronicle of Cardiogenic Shock, Renal Failure, Vasculitis-Like Lesions, and Disseminated Intravascular Coagulation.

Oct 18, 2021

Catastrophic antiphospholipid syndrome (CAPS) is a rare disorder characterized by a storm of thrombosis leading to rapidly progressive multiple organ damage and thus needs to be picked earlier in the ...

Defining renal remission in an international cohort of 248 children and adolescents with lupus nephritis.

Oct 11, 2021

We studied the rate of remission of lupus nephritis (LN) in an international cohort of 248 children and adolescents with biopsy proven LN. Five different definitions from scientific studies and the de...

Alterations of serum trace elements and other biochemical parameters are correlated with the pathogenesis of systemic lupus erythematosus: A preliminary study on Bangladeshi population.

Sep 27, 2021

Systemic lupus erythematosus (SLE) is an autoimmune disorder in which the body's defense system wrongly attacks healthy body tissues. The objective of this current setup was to quantify and compare th...