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Osteoporosis

Disruption of the aldehyde dehydrogenase 2 gene increases the bone anabolic response to intermittent PTH treatment in an ovariectomized mouse model.

Apr 24, 2020

Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that oxidizes the acetaldehyde produced by alcohol metabolism. This variant not only affects the response to alcohol but is also associated with several ...

Impact of osteoporosis on different type of short-segment posterior instrumentation for thoracolumbar burst fracture - a finite element analysis.

Apr 24, 2020

In Taiwan (my country), the proportion of people 65 years or older is over 14% in 2018, which is known as entering "aged society". More and more thoracolumbar burst fractures in the setting of osteopo...

Simultaneous fluorescence and quantitative phase imaging of MG63 osteosarcoma cells to monitor morphological changes with time using partially spatially coherent light source.

Apr 24, 2020

Quantitative phase imaging (QPI) technique is used to determine various biophysical parameters, such as refractive index, cell thickness, morphology, etc. On the other hand, fluorescence microscopy is...

CME: The Impact of Physical Activity & Sedentary Behavior on Fracture Risk

Apr 14, 2020

This course discusses a study that assessed the associations of physical activity and sedentary behavior with fracture incidence among postmenopausal women aged 50 to 79 years....

Correlates of participation in physical activity among older women in Israel: does ethno-cultural background matter?

Apr 12, 2020

Osteoporosis and its related fractures are major public health concerns. Physical activity (PA) is crucial for bone density preservation and fractures prevention. Yet, gaps in understanding exist rega...

Efficacy and safety of upadacitinib in Japanese patients with rheumatoid arthritis (SELECT-SUNRISE): a placebo-controlled phase IIb/III study.

Apr 12, 2020

To evaluate upadacitinib efficacy and safety dose response in Japanese patients with active RA and an inadequate response to conventional synthetic DMARDs (csDMARDs).This was a multicentre, phase IIb/...

Measuring Advanced/Extended Practice Roles in Arthritis and Musculoskeletal Care in Canada.

Apr 12, 2020

Our objective was to characterize Canadian workforce attributes of extended role practitioners (ERPs) in arthritis care.We used an exploratory, mixed-methods study that was based on the Canadian Rheum...

Evaluating two nanocarrier systems for the transdermal delivery of sodium alendronate.

Apr 12, 2020

Sodium alendronate is a nitrogen-containing bisphosphonate, widely used for osteoporosis treatment. However, due to its several oral administration drawbacks, the transdermal route represents an inter...

Osteoporosis Trends & Disparities

Apr 08, 2020

Data indicate that the declining trend of hip fracture among Americans plateaued in 2012 before increasing through present day. “Since hip fractures are the most common result of osteoporosis, this ...

Integrative proteomics-metabolomics strategy reveals the mechanism of hepatotoxicity induced by Fructus Psoraleae.

Apr 03, 2020

Fructus Psoraleae (FP), one of the significant traditional Chinese medicines, has been reported to cause hepatotoxicity. However, the mechanism remains undetermined and the reported research is limite...

Can bone mineral density loss in the non-weight bearing distal forearm predict mortality?

Apr 03, 2020

Low bone mineral density (BMD) is associated with increased risk of fractures and mortality. We investigated if rate of BMD loss in the distal forearm over seven years predicted mortality.1725 postmen...

Association between IL1B polymorphisms and the risk of rheumatoid arthritis.

Apr 03, 2020

Rheumatoid arthritis (RA) is a chronic, inflammatory synovitis dominated systemic disease with unknown etiology. The purpose of this study was to determine the relationship between IL1B polymorphisms ...

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases.

Mar 24, 2020

Excessive release of neutrophil extracellular traps (NETs) is associated with disease severity and contributes to tissue injury, followed by severe organ damage. Pharmacological or genetic inhibition ...

An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling.

Mar 24, 2020

T-cell receptor (TCR) signaling is initiated by recruiting ZAP-70 to the cytosolic part of TCR. ZAP-70, a non-receptor tyrosine kinase, is composed of an N-terminal tandem SH2 (tSH2) domain connected ...

Testing a self-determination theory-based process model of physical activity behavior change in rheumatoid arthritis: results of a randomized controlled trial.

Mar 24, 2020

Physical inactivity is prevalent in rheumatoid arthritis (RA) patients, increasing the risk of poor physical health and compromised well-being. Interventions are therefore required to support physical...

Osteoporosis, BMD & Fracture Risk in PLHIV

Mar 24, 2020

With significant improvements in the treatment of HIV in recent years, life expectancy in patients living with HIV (PLHIV) has increased dramatically and is now near to that of the general populatio...

Association between bile acid metabolism and bone mineral density in postmenopausal women.

Mar 19, 2020

Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association...

Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.

Mar 19, 2020

Intrinsic complement C3 activity is integral to human T helper type 1 (Th1) and cytotoxic T cell responses. Increased or decreased intracellular C3 results in autoimmunity and infections, respectivel...

The Borrelia burgdorferi VlsE Lipoprotein Prevents Antibody Binding to an Arthritis-Related Surface Antigen.

Mar 19, 2020

Arp is an immunogenic protein of the Lyme disease spirochete Borrelia burgdorferi and contributes to joint inflammation during infection. Despite Arp eliciting a strong humoral response, antibodies fa...

Bioactive fractions from Securidaca inappendiculata alleviated collagen-induced arthritis in rats by regulating metabolism-related signaling.

Mar 19, 2020

Securidaca inappendiculata is a xanthone rich medicinal plant that has been used in the treatment of inflammation and autoimmune diseases like rheumatoid arthritis (RA) for centuries; however, the mat...