Advertisement

Neurosurgery

Combination of cyclic nucleotide modulators with P2Y receptor antagonists as anti-platelet therapy.

Apr 12, 2020

Endothelium-derived prostacyclin and nitric oxide elevate platelet cyclic nucleotide levels and maintain quiescence. We previously demonstrated a synergistic relationship exists between cyclic nucleot...

Peer-to-Peer Contact Tracing: A Privacy-Preserving Smartphone Application.

Apr 03, 2020

The novel coronavirus disease 2019 (COVID-19) pandemic is an urgent public health crisis, with epidemiologic models predicting severe consequences, including high death rates, if the virus is permitte...

Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase.

Apr 03, 2020

This study aimed to analyse the effects of clotrimazole (CTZ) on estrogen production pathway in endometriosis progression. Experimental endometriosis was induced by autologous transplantation in femal...

A robust and novel electrical impedance metric of pulmonary function in ALS patients.

Apr 03, 2020

Pulmonary function tests (PFTs) are important for assessing respiratory function in amyotrophic lateral sclerosis (ALS) patients. However, weakness of oral and glottal closure, due to concomitant bulb...

Enhanced transcutaneous electrical nerve stimulation achieved by a localized virtual bipole: A computational study of human tibial nerve stimulation.

Apr 03, 2020

Electrical neuromodulation is a clinically effective therapeutic instrument, currently expanding into newer indications and larger patient populations. Neuromodulation technologies are also moving tow...

The Clinical Significance of Seminoma Component in Testicular Mixed Germ Cell Tumour.

Apr 03, 2020

The aim of this study was to examine clinical/pathological characteristics, prognosis and tendency to metastasis of mixed germ cell tumours (MGCTs) that contain a seminoma component.A total of 111 MGC...

Real-world clinical diagnostics of heart failure patients with reduced or preserved ejection fraction.

Mar 19, 2020

The study aimed at investigating the use of guideline-recommended diagnostic tools and medication in patients with heart failure (HF) in specialty care in Southwest Finland. We also compared the chara...

Assessment of sidestream end-tidal capnography in ventilated infants on the neonatal unit.

Mar 19, 2020

Continuous monitoring of carbon dioxide (CO ) levels can be achieved by capnography. Our aims were to compare the performance of a sidestream capnograph with a low dead space and sampling rate to a ma...

A mechanistic study and review of volatile products from peroxidation of unsaturated fatty acids: an aid to understanding the origins of volatile organic compounds from the human body.

Mar 13, 2020

The assessment of volatile compounds (VOCs) for disease diagnosis is a growing area of research. There is a need to provide hard evidence i.e. biochemical routes, to justify putative VOC biomarkers, a...

Inhibition of Interleukin-6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice.

Mar 13, 2020

The role of IL-6 signalling in hypertensive heart disease and its sequelae is controversial. Our group demonstrated that Bazedoxifene suppressed IL-6/gp130 signalling in cancer cells but its effect on...

N -methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes.

Mar 10, 2020

Non-alcoholic fatty liver disease (NAFLD) is characterized by accumulation of excessive triglycerides (TGs) in hepatocytes. Obesity is a major risk factor for developing fatty liver, although the intr...

Comparing TEE vs Non-TEE guided cardioversion of atrial fibrillation: the ENSURE-AF trial.

Mar 10, 2020

ENSURE-AF (NCT02072434) assessed therapy with edoxaban versus enoxaparin-warfarin in patients with nonvalvular atrial fibrillation (AF) undergoing elective electrical cardioversion (ECV).To evaluate c...

Tuning Cytokines Enriches Dendritic Cells and Tregs in the Periodontium.

Mar 10, 2020

Periodontal disease results from the pathogenic interactions between the tissue, immune system, and microbiota; however, standard therapy fails to address the cellular mechanism underlying the chronic...

Infectious complications after hematopoietic stem cell transplantation for primary immunodeficiency in children: a multicenter nationwide study.

Mar 10, 2020

The aim of this nation-wide study was to evaluate the characteristics of bacterial (BI), invasive fungal disease (IFD) and viral infections (VI) in pediatric patients with PID after allogeneic hematop...

Lumbar Puncture Guidance

Mar 09, 2020

Data indicate that nearly 400,000 lumbar punctures (LPs) are performed annually for either diagnostic workup or therapeutic relief in the United States. Regular referral to radiology for assistance ...

Detecting Social and Behavioral Determinants of Health with Structured and Free-Text Clinical Data.

Mar 05, 2020

 Social and behavioral determinants of health (SBDH) are environmental and behavioral factors that often impede disease management and result in sexually transmitted infections. Despite their import...

[Effects of Noise Protection Measures on Annoyance, Sleep Disorders, and Cardiovascular Diseases: A Model Calculation].

Mar 05, 2020

In Germany, traffic noise-related threshold values are currently set at 70 decibels (dB) during the day and 60 dB at night. According to recent study results, these threshold values might not sufficie...

Parvovirus B19 infection in sickle cell disease: An analysis from the Centers for Disease Control haemoglobinopathy blood surveillance project.

Mar 05, 2020

In the multicentre Haemoglobinopathy Blood Surveillance Project, to evaluate the seroprevalence of parvovirus B19 and DNA viral load in sickle cell disease (SCD).Although the epidemiology of parvoviru...

Biology-inspired microphysiological systems to advance medicines for patient benefit and animal welfare.

Mar 02, 2020

The first microfluidic microphysiological systems (MPS) entered the academic scene more than 15 years ago and were considered an enabling technology to human (patho)biology in vitro and, therefore, pr...

Patient knowledge, experiences and preferences regarding retinoblastoma and research: A qualitative study.

Mar 02, 2020

We launched a patient engagement strategy to facilitate research involvement of the retinoblastoma (childhood eye cancer) community in Canada. To inform our strategy, we aimed to uncover the experienc...