Assessing the Impact of Distance to Kidney Transplant Centers
Most patients with end-stage kidney disease (ESKD) who are on dialysis will need to be referred...
Transplantation
Covid-19: High Mortality Seen in Heart Transplant Patients
Small series points to complex issues for HT patients with Covid-19 Over an 8-week period beginning March 1, doctors at a large academic medical center in New York confirmed SARS-CoV-2 infection in 28 heart transplant patients,...
Deceased Donor Kidneys With AKI & Recipient Graft Survival
According to current estimates, 95,000 patients with end-stage renal disease (ESRD) in the United...
Evidence for the alloimmune basis and prognostic significance of Borderline T cell-mediated rejection.
Prognostic biomarkers of T cell-mediated rejection (TCMR) have not been adequately studied in the modern era. We evaluated 803 renal transplant recipients and correlated HLA-DR/DQ molecular mismatch alloimmune risk categories...
Pain expectancy, prevalence, severity, and patterns following donor nephrectomy: Findings from the KDOC Study.
Postoperative pain is an outcome of importance to potential living kidney donors. We prospectively characterized the prevalence, severity and patterns of acute or chronic postoperative pain in 193 LKDs at six transplant...
T cell exhaustion is associated with antigen abundance and promotes transplant acceptance.
Exhaustion of T cells limits their ability to clear chronic infections or eradicate tumors. Here, in the context of transplantation, we investigated whether T-cell exhaustion occurs and has a role in determining transplant...
IgA Nephropathy Recurrence after Kidney Transplantation: Role of Recipient Age and Human Leukocyte Antigen-B Mismatch.
Recurrence of immunoglobulin (Ig)A nephropathy (rIgAN) is a growing cause of kidney allograft dysfunction. This study was aimed at investigating factors associated with rIgAN and the subsequent progression to end-stage renal...
Developments in consolidation and maintenance strategies in post-remission multiple myeloma.
: Multiple Myeloma (MM) is a very heterogeneous clonal plasma cell hematological malignancy for which new therapies and transplantation effectively improve Progression-free survival (PFS) and overall survival (OS). Maintenance...
Utilization of Direct Acting Oral Anticoagulation in Solid Organ Transplant Patients: A National Survey of Institutional Practices.
The safety and efficacy of direct acting oral anticoagulants (DOACs) and reversal strategies are not well established in the solid organ transplant population. This was a survey of pharmacists to assess DOAC and urgent reversal...
Pharmacogenetic-Whole blood and intracellular pharmacokinetic-Pharmacodynamic (PG-PK2-PD) relationship of tacrolimus in liver transplant recipients.
Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating the interplay between pharmacogenetic determinants of TAC whole blood and intracellular exposures as well...
Delayed versus initial cytomegalovirus prophylaxis after kidney transplantation.
It is recommended to start cytomegalovirus (CMV) prophylaxis within ten days of solid organ transplant, if indicated. Our center underwent a cost-savings initiative to delay CMV prophylaxis initiation from postoperative day zero...
Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.
Acute kidney injury (AKI) is a major comorbidity in hospitalised patients. Patients with severe AKI require continuous renal replacement therapy (CRRT) when they are haemodynamically unstable. CRRT is prescribed assuming it is...
