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Transplantation

Toward continuous improvement of Scientific Registry of Transplant Recipients performance reporting: Advances following 2012 consensus conference and future consensus building for 2022 consensus conference.

May 23, 2022

The Scientific Registry of Transplant Recipients (SRTR) held a consensus conference in 2012 that examined methods used by SRTR for constructing performance metrics and made recommendations on how to i...

Multi-photon microscopy for the evaluation of interstitial fibrosis in extended criteria donor kidneys: A Proof-of-Concept Study.

May 23, 2022

To evaluate the initial use of label-free second harmonic generation (SHG) imaging with two-photon excitation (2PE) auto-fluorescence in multi-photon microscopy (MPM) for the quantification of collage...

Temporal shift and predictive performance of machine learning for heart transplant outcomes.

May 16, 2022

Outcome prediction following heart transplant is critical to explaining risks and benefits to patients and decision-making when considering potential organ offers. Given the large number of potential ...

Unresolved issues in allogeneic hematopoietic cell transplantation for non-malignant diseases.

May 16, 2022

Allogeneic hematopoietic cell transplantation (HCT) can be curative for a variety of non-malignant diseases (NMDs) as well as hematological malignancies. However, there are several fundamental differe...

Loneliness in adults awaiting liver transplantation at 7 U.S. transplant centers.

Apr 25, 2022

Loneliness, "a subjective feeling of being isolated", is a strong predictor of adverse health. We characterized loneliness in patients with end-stage liver disease (ESLD) awaiting liver transplantatio...

Feasibility and efficacy of partially replacing post-transplant cyclophosphamide with bendamustine in pediatric and young adult patients undergoing haploidentical bone marrow transplantation.

Apr 25, 2022

Post-transplant cyclophosphamide (PT-CY) is the most widely applied graft-versus-host disease (GvHD) prophylaxis regimen in T-cell replete haploidentical bone marrow transplantation (haplo-BMT). While...

Safety of percutaneous, image-guided biopsy of hepatocellular carcinoma with and without concurrent ablation.

Apr 11, 2022

To determine the prevalence of adverse events after image-guided biopsy of histologically proven hepatocellular carcinomas (HCC) using a standardized, indirect access, coaxial biopsy technique.In this...

Strain-resolved analysis in a randomized trial of antibiotic pretreatment and maintenance dose delivery mode with fecal microbiota transplant for ulcerative colitis.

Apr 04, 2022

Fecal microbiota transplant is a promising therapy for ulcerative colitis. Parameters maximizing effectiveness and tolerability are not yet clear, and it is not known how import the transmission of do...

TCRαβ-Depleted Haploidentical Grafts Are a Safe Alternative to HLA-Matched Unrelated Donor Stem Cell Transplants for Infants with Severe Combined Immunodeficiency.

Mar 21, 2022

Hematopoietic stem cell transplantation and gene therapy are the only curative therapies for severe combined immunodeficiency (SCID). In patients lacking a matched donor, TCRαβ/CD19-depleted haploid...

Comparative assessment of immunological tolerance in fish with natural immunodeficiency.

Mar 14, 2022

Natural occurrences of immunodeficiency by definition should lead to compromised immune function. The major histocompatibility complexes (MHC) are key components of the vertebrate adaptive immune syst...

Risk of Perioperative Stroke in Patients with Patent Foramen Ovale: A Systematic Review and Meta-Analysis.

Mar 07, 2022

Patent foramen ovale (PFO) is a common congenital cardiac abnormality. Risk of stroke increases perioperatively; however, the association of PFO with perioperative stroke risk remains unclear. We cond...

Patterns and predictors of functional decline after alloHCT in older adults.

Mar 07, 2022

As allogeneic hematopoietic cell transplantation (alloHCT) is increasingly offered to older adults, geriatric assessments (GA) have been identified as a useful tool for predicting outcomes, particular...

Hematopoietic Stem Cell Transplantation in Nepal: international partnership, implementation steps and clinical outcomes.

Feb 21, 2022

Blood & Marrow Transplantation (BMT) is rarely available in many low-middle-income countries (LMIC). In 2012, Civil Service Hospital, a government hospital in Kathmandu (Nepal) partnered with the ...

Effective Letermovir Prophylaxis of CMV infection post allogeneic hematopoietic cell transplantation: Results from the French temporary authorization of use compassionate program.

Feb 21, 2022

We report the results of the French Temporary Authorization of Use (ATU) compassionate program of letermovir for primary prophylaxis conducted in 21 transplant centers. Patients were CMV seropositive ...

A Comparison of Methods to Detect Changes in Prediction Models.

Feb 14, 2022

 Prediction models inform decisions in many areas of medicine. Most models are fitted once and then applied to new (future) patients, despite the fact that model coefficients can vary over time due ...

Real-world eligibility for second-line CAR-T cell therapy in large B-cell lymphoma: a population-based analysis.

Feb 07, 2022

The ZUMA-7 trial demonstrated the superiority of second-line CAR-T cell therapy over standard of care chemotherapy +/- autotransplant for relapsed/refractory (r/r) large B-cell lymphoma (LBCL). We con...

A fludarabine and melphalan reduced-intensity conditioning regimen for HSCT in fifteen chronic granulomatous disease patients and a literature review.

Jan 10, 2022

Chronic granulomatous disease (CGD) is a life-threatening immunodeficiency condition. To date, hematopoietic stem cell transplantation (HSCT) is the only curative modality. We prospectively studied th...

Nutritional support practices and opinions toward gastrostomy use in pediatric bone marrow transplant centers: A national survey.

Jan 10, 2022

Previous surveys have shown deviations in nutritional practices from international guidelines during bone marrow transplant (BMT). Guidelines recommend enteral nutrition first-line and nasogastric tub...

Long-term Clinical Outcomes of Severe Combined Immunodeficiency Patients Given Nonablative Marrow Transplants.

Dec 27, 2021

Severe Combined Immunodeficiency (SCID) is a syndrome characterized by profound T cell deficiency that is universally fatal in infancy unless immune reconstitution is achieved by hematopoietic stem ce...

Global and regional white matter fractional anisotropy in children with chronic kidney disease.

Nov 15, 2021

To investigate the associations between neurocognition and white matter integrity in children with chronic kidney disease.This cross-sectional study included 17 boys (aged 6-16 years) with a diagnosis...