Laboratory medicine 2016 10 1948(1) 57-64 doi 10.1093/labmed/lmw053
To evaluate cluster of differentiation (CD)127 expression in T cells of patients with HIV-1 and the relationship of CD127 expression with disease progression.
We divided 139 patients infected with human immunodeficiency virus type 1 (HIV-1) who had undergone highly active antiretroviral therapy (HAART) into 3 groups: patients with poor recovery (CD4(+)T < 350/μ;L, patients with general recovery (CD4(+)T = 350 - ∼600/μL) and patients with good recovery (CD4(+)T > 600/μL). Counts and percentages of naïve (CD45RA(+)) and memory (CD45RO(+)) T cells and CD127 expression were determined using flow cytometry.
CD4(+)CD45RO(+), CD4(+)CD45RA(+), CD4(+) CD45RO(+) CD127(+), and CD4(+)CD45RA(+)CD127(+)T-cell counts in patients with good recovery were higher than in patients with poor recovery and those with general recovery patients (P <.05). Percentages of CD45RO(+) were increased, and percentages of CD45RA(+) and CD127 in T cells were decreased in patients with poor and general recovery (P <.05). CD127 values were positively correlated with CD4(+)T-cell counts and percentages of CD45RA(+) subsets (P <.05). CONCLUSION
CD127 expression in T cells is decreased in patients with HIV-1 and is related to recovery of CD4(+)T-cell counts and to naïve subsets.