Journal of acquired immune deficiency syndromes (1999) 2017 02 14() doi 10.1097/QAI.0000000000001322
Natural killer T (NKT) cells act as a bridge between innate and adaptive immune responses. Limited information is available regarding the role of NKT cells in the HIV disease progression especially HIV-1 C infection.
NKT cells were characterized for their frequency and the activation, aging, exhaustion status and their proliferation ability in 32 long term non progressors (LTNPs), 40 progressors, 18 patients before and after suppressive cART along with 35 HIV-1 negative subjects using multicolor flowcytometry.
The frequencies of total NKT cells and their subpopulation were significantly higher in LTNPs as compared with those obtained in progressors (p<0.0001) and was significantly associated with higher CD4 counts, and with lower plasma viral loads (pVL). The percentage of activated, aged and exhausted NKT cells were significantly lower in LTNPs as compared to the progressors and inversely correlated with CD4 count and positively with pVL. The NKT cells from the LTNPs showed higher proliferation ability. The frequency and proliferation ability of the NKT cells were partially restored after 12 months of suppressive cART but still lower than the levels in LTNPs. The degree of restoration after cART was similar in both CD4+ and CD4- NKT cells. CONCLUSION
The findings demonstrate significant association of preserved NKT cells with the non-progressive HIV infection and also showed that exhausted NKT cells are associated with disease progression. Further characterization of their functionality and assessment of sustenance in HIV infection will help to understand the HIV pathogenesis and to develop immune therapies.