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CD8(+) T cell expansion in HIV/HCV coinfection is associated with systemic inflammation.

CD8(+) T cell expansion in HIV/HCV coinfection is associated with systemic inflammation.
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Saidakova EV, Shmagel KV, Korolevskaya LB, Shmagel NG, Chereshnev VA,


Saidakova EV, Shmagel KV, Korolevskaya LB, Shmagel NG, Chereshnev VA, (click to view)

Saidakova EV, Shmagel KV, Korolevskaya LB, Shmagel NG, Chereshnev VA,

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Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 2017 07 13474(1) 126-128 doi 10.1134/S0012496617030024

Abstract

High prevalence of non-AIDS-defining illnesses in treated HIV-infected patients is associated with increased peripheral CD8(+) T cell counts. Hepatitis C virus (HCV) coinfection is an additional risk factor for the development of non-AIDS events. We found that, in HIV/HCV coinfection, the increased proportion of CD8(+) T lymphocytes is due to the effector memory and terminal effector T cells gain. Moreover, in these patients, the accumulation of highly differentiated forms of CD8(+) T lymphocytes was associated with increased concentrations of inflammatory indices.

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