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Cellular and humoral immunity after vaccination or natural infection of mumps.

Cellular and humoral immunity after vaccination or natural infection of mumps.
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Terada K, Hagihara K, Oishi T, Miyata I, Akaike H, Ogita S, Ohno N, Ouchi K,


Terada K, Hagihara K, Oishi T, Miyata I, Akaike H, Ogita S, Ohno N, Ouchi K, (click to view)

Terada K, Hagihara K, Oishi T, Miyata I, Akaike H, Ogita S, Ohno N, Ouchi K,

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Pediatrics international : official journal of the Japan Pediatric Society 2017 04 22() doi 10.1111/ped.13306
Abstract
OBJECTIVE
This study measured cell-mediated immunity (CMI) and serum antibody levels to clarify the basis of breakthrough after vaccination and reinfection after mumps.

METHODS
From a pool of 54 college students, 17 seronegative subjects and 14 subjects with intermediate levels of antibodies against mumps were vaccinated with a monovalent mumps vaccine and CMI was assessed using an interferon-γ release assay.

RESULTS
CMI positivity in subjects classified by pre-existing antibody levels, which gave groups with titers of <2.0 (negative), 2.0~3.9 (intermediate), and ≥4.0 index units (positive), was 8/17 (47.1%), 9/14 (64.3%) and 19/23 (82.6%) before vaccination. Of the 17 seronegative subjects, 7 (41.2%) had a history of vaccination and/or natural infection, 4 (57.1%) of whom had CMI positive or intermediate. Ten (71%) of 14 subjects with intermediate levels had a history of vaccination or natural infection, and 8 (80%) of whom had CMI positive or intermediate. After vaccination the IFN-γ and antibody titers increased significantly, but 7 (41.2%) of the 17 seronegative subjects and 13 (92.9%) of the 14 subjects with intermediate levels tested positive for both antibody and CMI. In a comparison of the natural infection group (confirmed with IgG seropositive and/or CMI positive without vaccination) vs. the vaccination group, the IgG antibody titers (mean ± SD) were 14.4 ± 8.0 vs. 3.6 ± 2.4 index units (p<0.01) and the IFN-γ values were 122.7 ± 90.0 pg/mL vs. 59.5 ± 37.8 pg/mL (p>0.05), respectively.

CONCLUSION
Vaccination or even natural mumps infection did not always induce both cellular and humoral immunity. This article is protected by copyright. All rights reserved.

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