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Cervical microbiome is altered in cervical intraepithelial neoplasia after loop electrosurgical excision procedure in china.

Cervical microbiome is altered in cervical intraepithelial neoplasia after loop electrosurgical excision procedure in china.
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Zhang H, Lu J, Lu Y, Cai Q, Liu H, Xu C,


Zhang H, Lu J, Lu Y, Cai Q, Liu H, Xu C, (click to view)

Zhang H, Lu J, Lu Y, Cai Q, Liu H, Xu C,

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Scientific reports 2018 03 218(1) 4923 doi 10.1038/s41598-018-23389-0

Abstract

Although human papillomavirus (HPV) infection is a major cause leading to the development of cervical intraepithelial neoplasia (CIN), the relationship between genital microbiome and HPV persistence/clearance is not well established. Loop electrosurgical excision procedure (LEEP) is one of standard treatments of CIN 2/3 globally, yet little is known about how the LEEP influence genital microbiota. We conducted a prospective study of 26 patients with CIN2/3 who underwent analysis of cervical microbiome before and after 3 months of LEEP treatment. Cervical swabs were collected, and microbiomes were analyzed by 16S ribosomal RNA gene sequencing. A decrease of cervical microbial diversity was observed after 3 months of LEEP treatment. Notably, a significant shift from community type of a Prevotella-containing and lack of a consistent dominant species to lactobacillus iners dominated microbiome correlated with LEEP. Particularly, Leptotrichia and clostridium were further decreased after LEEP treatment (P = 0.049 and P = 0.002, respectively). Our results suggest that the cervical microbiome is altered after LEEP treatment in patients with CIN2/3. Further studies with larger sample sizes are needed to validate these findings.

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