For a study, researchers sought to understand that intravenous immunoglobulin (IVIg) contains pooled immunoglobulins from the plasma of sound blood givers. All plasma tests were tried for HIV, hepatitis virus (A, B, and C), and parvovirus B19. As a feature of this screening step, nucleic acid amplification technology (NAT) was utilized. It permits the presence of explicit antibodies focusing on viral designs that were normally used to test for contamination status, for example, as anti-hepatitis B surface antigen (HBs) or anti-hepatitis B virus core (HBc) antibodies. Hence, producers highlight the chance of false positive viral serological experimental outcomes following IVIg treatment because of the inactive exchange of antibodies. IVIg treatment was ordinarily used to oversee patients with serious, treatment-obstinate immune system skin illnesses. The point of this associate review was to reflectively measure newfound positive serological HBV test results after IVIg treatment in patients with immune system skin illnesses. Between March 2018 and June 2021, 28 patients with immune system skin sicknesses got IVIg treatment, of whom 17 were longitudinally followed up. None of the patients had proof of dynamic HBV disease before IVIg treatment. All patients (n=17) had discernible enemies of HBs antibodies, and 12 patients were hostile to HBc antibodies a month after starting IVIg treatment. Detached immune response move appears to be the most probable understanding. A complete serological hepatitis evaluation ought to be performed to prohibit another disease. Investigators prescribed hepatitis screening before IVIg treatment to forestall symptomatic disarray, which might emerge from an inactive neutralizer move.