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Changes in management policies for extremely preterm births and neonatal outcomes from 2003 to 2012: two population-based studies in 10 European regions.

Changes in management policies for extremely preterm births and neonatal outcomes from 2003 to 2012: two population-based studies in 10 European regions.
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Bonet M, Cuttini M, Piedvache A, Boyle EM, Jarreau PH, Kollée L, Maier RF, Milligan DW, Van Reempts P, Weber T, Barros H, Gadzinowki J, Draper ES, Zeitlin J, ,


Bonet M, Cuttini M, Piedvache A, Boyle EM, Jarreau PH, Kollée L, Maier RF, Milligan DW, Van Reempts P, Weber T, Barros H, Gadzinowki J, Draper ES, Zeitlin J, , (click to view)

Bonet M, Cuttini M, Piedvache A, Boyle EM, Jarreau PH, Kollée L, Maier RF, Milligan DW, Van Reempts P, Weber T, Barros H, Gadzinowki J, Draper ES, Zeitlin J, ,

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BJOG : an international journal of obstetrics and gynaecology 2017 03 14() doi 10.1111/1471-0528.14639
Abstract
OBJECTIVE
to investigate changes in maternity and neonatal unit policies towards extremely preterm infants (EPTI) between 2003 and 2012 and concurrent trends in their mortality and morbidity in ten European regions.

DESIGN
population-based cohort studies in 2003 (MOSAIC study) and 2011/12 (EPICE study) and questionnaires from hospitals.

SETTING
70 hospitals in ten European regions.

POPULATION
infants born at <27 weeks of gestational age (GA) in hospitals participating in both the MOSAIC and EPICE studies (1240 in 2003, 1293 in 2011/2012). METHODS
We used McNemar’s Chi2 test, paired t-tests and conditional logistic regression for comparisons over time.

MAIN OUTCOMES MEASURES
reported policies, mortality and morbidity of EPTI.

RESULTS
The lowest GA at which maternity units reported performing a caesarean section for acute distress of a singleton non-malformed fetus decreased from an average of 24.7 to 24.1 weeks (p<0.01) when parents were in favour of active management and 26.1 to 25.2 (p=0.01) when parents were against. Units reported that neonatologists were called more often for spontaneous deliveries starting at 22 weeks GA in 2012 and more often made decisions about active resuscitation alone, rather than in multidisciplinary teams. In-hospital mortality after live birth for EPTI decreased from 50% to 42% (p<0.01). Units reporting more active management in 2012 than 2003 had higher mortality in 2003 (55% vs. 43%, p<.01) and experienced larger declines (55% to 44%; p<0.001) than units where policies stayed the same (43% to 37%; p=0.1). CONCLUSIONS
European hospitals reporting changes in management policies experienced larger survival gains for EPTI. This article is protected by copyright. All rights reserved.

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