The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2017 05 28() 1-20 doi 10.1080/14767058.2017.1336224
To describe the characteristics of abnormal OGTT values at GDM diagnosis and their associations with clinical characteristics, and to evaluate the effect on GDM diagnosis if any OGTT value was omitted.
MATERIALS AND METHODS
A cross-sectional study was conducted in 415 women diagnosed with GDM. The OGTT results were recorded and analyzed.
Of 415 included women, mean gestational age at GDM diagnosis was 19.2 weeks and 57.6% were diagnosed before 20 weeks. The highest proportions of abnormal values were found at the 1(st) and 2(nd) hour (85.3% and 96.6%, respectively). If the 3(rd) hour OGTT value was omitted, 16.7% of GDM cases would be missed. Number of abnormal OGTT values and abnormal FPG were significantly associated with obesity. Only pre-pregnancy overweight and obesity independently associated with insulin requirement (adjusted OR: 2.28, 95%CI: 1.02-5.06; p = 0.044; and adjusted OR: 6.29, 95%CI: 2.67-14.85; p < 0.001, respectively). CONCLUSION
Over half of GDM women had 3 or 4 abnormal OGTT values. Omission of the 3(rd) hour OGTT value would result in 16.7% of patients not being diagnosed with GDM. Number of abnormal OGTT values and abnormal FPG were associated with obesity, and insulin requirement was associated with pre-pregnancy overweight and obesity.