Antibiotic effectiveness in rosacea therapy implies a role for microorganisms in its pathogenesis. The growing worry about the negative consequences of antibiotic usage necessitates the adoption of tailored antimicrobial therapy in rosacea. Researchers conducted a case–control research to compare the skin microbiota of rosacea patients to controls who were age, gender, and race matched. Nineteen people with rosacea, erythematotelangiectatic rosacea, papulopustular rosacea, or both were matched to 19 people without rosacea. DNA was collected from skin swabs taken from individuals’ noses and bilateral cheeks. The V3V4 region of the bacterial 16S ribosomal RNA gene was sequenced with an Illumina MiSeq and analysed with QIIME/MetaStats 2.0 software. Skin microbiota in erythematotelangiectatic rosacea was decreased in Roseomonas mucosa compared to controls. Campylobacter ureolyticus, Corynebacterium kroppenstedtii, and the oral flora Prevotella intermedia were shown to be abundant in papulopustular rosacea. C. kroppenstedtii was found in the highest relative abundance in individuals with both erythematotelangiectatic and papulopustular rosacea, followed by papulopustular and erythematotelangiectatic rosacea. C. kroppenstedtii was likewise linked to more severe illness, with the highest relative abundance in rosacea affecting both the cheeks and the nose, followed by rosacea sparing the nose and controls.
The skin microbiota of people with rosacea differs from that of healthy skin, indicating that more research into the skin microbiota’s possible role in the pathophysiology of rosacea is required.
Reference:https://link.springer.com/article/10.1007/s40257-019-00471-5
