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Characterization of a Novel HIV-1 Second-Generation Recombinant Form in Men Who Have Sex with Men in Beijing, China.

Characterization of a Novel HIV-1 Second-Generation Recombinant Form in Men Who Have Sex with Men in Beijing, China.
Author Information (click to view)

Wang C, Wang Y, Kong D, Xin R, Xu W, Feng Y, Shao Y, Ma L,


Wang C, Wang Y, Kong D, Xin R, Xu W, Feng Y, Shao Y, Ma L, (click to view)

Wang C, Wang Y, Kong D, Xin R, Xu W, Feng Y, Shao Y, Ma L,

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AIDS research and human retroviruses 2017 08 10() doi 10.1089/AID.2017.0143

Abstract

Co-circulation of multiple subtypes in same population contributes significantly to the emergence of recombinant viruses. BJ2015EU19, a novel CCR5-tropic HIV-1 second-generation recombinant virus,was isolated from a man who has sex with man in Beijing, China. Phylogenetic analysis of the near full-length genome showed that BJ2015EU19 was consisted of seven fragments from CRF01_AE and CRF07_BC. There were six recombinant breakpoints in the pol, vpu, env and nef genes of BJ2015EU19,which were different from the other circulating recombinant forms and unique recombinant forms. The newly emergence of the unique recombinant form increases the complexity of the HIV epidemic in Chinese homosexual group, and the ongoing generation of recombinant viruses may provide an important basis for future analysis the recombination mechanism of HIV-1.

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