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CHARACTERIZATION OF CLINICAL PREDICTORS OF NATURALLY OCCURRING NS3/NS4A PROTEASE POLYMORPHISM IN GENOTYPE 1 HEPATITIS C VIRUS MONO AND HIV CO-INFECTED PATIENTS.

CHARACTERIZATION OF CLINICAL PREDICTORS OF NATURALLY OCCURRING NS3/NS4A PROTEASE POLYMORPHISM IN GENOTYPE 1 HEPATITIS C VIRUS MONO AND HIV CO-INFECTED PATIENTS.
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Lisboa Neto G, M Malta F, Gomes-Gouvêa MS, F Noble C, Malta Romano C, Renato R Pinho J, H da Silva M, Gb Leite A, Z Piccoli L, J Carrilho F, Cássia Mendes-Correa M,


Lisboa Neto G, M Malta F, Gomes-Gouvêa MS, F Noble C, Malta Romano C, Renato R Pinho J, H da Silva M, Gb Leite A, Z Piccoli L, J Carrilho F, Cássia Mendes-Correa M, (click to view)

Lisboa Neto G, M Malta F, Gomes-Gouvêa MS, F Noble C, Malta Romano C, Renato R Pinho J, H da Silva M, Gb Leite A, Z Piccoli L, J Carrilho F, Cássia Mendes-Correa M,

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Journal of medical virology 2017 07 12() doi 10.1002/jmv.24900

Abstract

Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or HCV/HIV co-infected patients. Fourteen samples (5.7%) harbored at least one resistance-associated substitution (RAS). The following RASs were detected in NS3 region: T54S (6 – 2.4%), V55A (7 – 2.8%) and Q80R (2 – 0.8%). S122G occurred in 86.9% of HCV genotype 1b samples with either natural polymorphisms or RASs. Advanced liver fibrosis and HIV co-infection were not related to NS3/NS4A amino acid substitutions. This article is protected by copyright. All rights reserved.

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