There aren’t many pediatric studies on the phenotypic features of eosinophilic esophagitis (EoE). For a study, researchers sought to potentially describe children from Europe and Israel who have EoE; the pEEr registry was created.

A prospective registry that accepts kids with esophageal eosinophilia (≥15 eos/HPF) is called pEEr. Data anonymized were gathered from 19 pediatric facilities. The following information was gathered: demographics, clinical symptoms, endoscopy, histology, and treatments.

A total of 582 subjects—61% of whom were men—were examined. The age at symptom start was 9.2 years (interquartile range (IQR): 4.3-16.4), whereas the median age at diagnosis was 10.5 years (IQR: 5.7-17.7). As a result, there was a median diagnostic delay of 1.2 years (IQR: 0.7–2.3). At the age of fewer than 6 years, the diagnostic delay was greater. Food allergies and EoE family history were linked to shorter diagnostic delays. Age-related differences in symptoms were seen, with dysphagia and food impaction being more prevalent in adolescents, while vomiting and undernutrition were more prevalent in younger children (P<0.001). Esophageal rings and exudates were the most prevalent endoscopic findings, respectively, in adolescents and younger children (P<0.001). Proton pump inhibitor (PPI)-responsive patients tended to be older, male, and less frequently had severe endoscopic findings. Patients who did not respond to PPIs were treated with topical steroids (40%), an elimination diet (41%), or a combination of treatments (19%).

Pediatric EoE has varying EoE results by age. Non-specific symptoms, atopic dermatitis, food allergies, and inflammatory endoscopic lesions are frequently seen in young children. Adolescents typically exhibit fibrostenotic lesions, dysphagia, or food impaction and a stronger PPI response.