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Characterization of HIV-1 subtypes and transmitted drug resistance among treatment-naive HIV-infected individuals in Zhejiang, China, 2014-2017.

Characterization of HIV-1 subtypes and transmitted drug resistance among treatment-naive HIV-infected individuals in Zhejiang, China, 2014-2017.
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Xu Y, Peng X, Peng X, Ji S, Chen B, Wang L, Lu X, Xie T, Sun T, Wang H, Wu N,


Xu Y, Peng X, Peng X, Ji S, Chen B, Wang L, Lu X, Xie T, Sun T, Wang H, Wu N, (click to view)

Xu Y, Peng X, Peng X, Ji S, Chen B, Wang L, Lu X, Xie T, Sun T, Wang H, Wu N,

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Archives of virology 2018 04 11() doi 10.1007/s00705-018-3839-1

Abstract

In recent years, transmitted drug resistance (TDR) has adversely impacted upon first-line therapy for HIV-infected individuals. To understand the current subtype distribution and TDR level in Zhejiang, China we performed phylogenetic analysis and genotypic drug resistance testing of treatment-naive HIV-infected individuals. A total of 153 HIV-1 Pol genes were successfully amplified. The distribution of HIV-1 genotypes was as follows: CRF01_AE (43.8%); CRF07_BC (37.9%); subtype B/B’ (7.2%); CRF08_BC (5.2%); and others (5.9%). Drug resistance analysis demonstrated that 11.1% of isolates contained at least one NRTI or NNRTI resistance-associated mutations while 2.0% were identified to be resistant to PIs. These findings enhance our understanding of the genetic diversity of HIV-1 strains circulating in Zhejiang and provide some guidelines for HIV initial treatment therapy.

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