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Characterization of naïve, memory and effector T cells in progressive multiple sclerosis.

Characterization of naïve, memory and effector T cells in progressive multiple sclerosis.
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Nielsen BR, Ratzer R, Börnsen L, von Essen MR, Christensen JR, Sellebjerg F,


Nielsen BR, Ratzer R, Börnsen L, von Essen MR, Christensen JR, Sellebjerg F, (click to view)

Nielsen BR, Ratzer R, Börnsen L, von Essen MR, Christensen JR, Sellebjerg F,

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Journal of neuroimmunology 2017 06 03310() 17-25 pii 10.1016/j.jneuroim.2017.06.001

Abstract

We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4(+) and CD8(+) T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26(+) CD28(+) CD4(+) TEMRA T cells were increased in all subtypes of MS, and CD26(+) CD28(+) CD8(+) TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d(+) CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

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