Chemokines are a large group of low molecular weight cytokines that attract and activate leukocytes throughout the body and therefore have a vital role in the framework of late-phase allergic responses. The purpose of this article is to provide an overview of the main chemokines involved in allergic conjunctivitis, their primary functions and their physiological roles, and therapies targeted at chemokines and their receptors for ocular allergic diseases.
There have been considerable advances in understanding the ocular pathophysiology of ocular surface inflammatory diseases, including allergic eye diseases and dry eye syndrome, in recent years. Several therapies being developed for dry eye inflammation are recognized as possible therapies for visual allergic disorders as there are often common chemokines involved in both disease spectra.
The study concluded that Chemokines represent an integral part of the late-phase cascade of ocular allergic inflammation. A deep understanding of specific chemokines and their interactions will help target therapies to effectively manage ocular clinical findings and symptoms of allergic eye disease. Further studies are required better to understand the role of Chemokines in allergic conjunctivitis, which can help in the treatment.