For a study, antimicrobial effects of vitamin D were discovered. Vitamin D and lower respiratory tract infection (LRTI) in children have had inconsistent results in research. For this systematic analysis, researchers wanted to determine how effective vitamin D supplementation was at preventing and treating LRTI in kids. Researchers looked for randomized controlled trials (RCTs) on vitamin D supplementation and LRTI in children. They extracted data from a structured form and did a meta-analysis. Vitamin D was utilized in varied quantities and for varying lengths of time in four trials including a total of 3,946 individuals. Supplementing with vitamin D had no effect on the occurrence of LRTI (odds ratio, 0.82; 95% CI; 0.47-1.45). When compared to placebo, vitamin D had no effect on the time to resolution of LRTI (mean difference, –0.01; 95% CI; –0.56 to 0.54). There were no notable negative effects associated with vitamin D administration.

The small number of RCTs investigating the efficacy of vitamin D supplementation on the prevention and treatment of LRTI in children found no benefit. More randomized controlled trials were needed to determine the optimal amount, frequency, and duration of vitamin D supplementation, as well as to identify particular categories of children who may benefit from supplementation.