THURSDAY, Feb. 20, 2020 (HealthDay News) — Chronic kidney disease (CKD) has a major effect on global health, both as a direct cause of morbidity and mortality and as a risk factor for cardiovascular disease, according to a study published online Feb. 13 in The Lancet.

Boris Bikbov, M.D., from the Istituto di Ricerche Farmacologiche Mario Negri IRCCS in Ranica, Italy, and colleagues used the published literature, vital registration systems, end-stage kidney disease registries, and household surveys to build models to estimate the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function.

The researchers found that in 2017, 1.2 million people globally died from CKD. The global, all-age mortality rate from CKD increased 41.5 percent from 1990 to 2017, but there was no significant change in the age-standardized mortality rate. In 2017, there were 697.5 million recorded cases of all-stage CKD with a global prevalence of 9.1 percent. The global all-age prevalence of CKD increased 29.3 percent during the study period, but the age-standardized prevalence remained stable. In 2017, 35.8 million disability-adjusted life-years (DALYs) were attributable to CKD, with diabetic nephropathy accounting for almost a third of DALYs. CKD burden was concentrated in the three lowest quintiles of the sociodemographic index. The burden of CKD was much higher than expected for the level of development in Oceania, sub-Saharan Africa, and Latin America, but it was lower than expected in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe. Impaired kidney function was tied to 1.4 million cardiovascular disease-related deaths and 25.3 million cardiovascular disease DALYs.

“CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle sociodemographic index,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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