This study was done to determine if CRS patients with nasal polyps (CRSwNP) differentially perceived CRS symptom burden compared to patients without nasal polyps (CRSsNP) and to what extent CRS symptom severity was associated with QOL and patient-reported symptom control in the 2 groups.

600 patients presenting with CRS were recruited. CRS symptom burden was assessed with the SNOT-22. SNOT-22 nasal, sleep, ear/facial discomfort, and emotional subdomain scores were calculated. General health-related QOL was assessed with the visual analog scale of the 5-dimensional EQ-5D VAS. Patients rated their CRS symptom control on a 5-point scale.

SNOT-22 scores did not differ between CRSwNP and CRSsNP. There were no differences in nasal, sleep, and emotional subdomains of the SNOT-22. CRSsNP had higher ear/facial subdomain scores than CRSwNP, while CRSwNP reported greater hyposmia. EQ-5D VAS was significantly lower in CRSsNP compared to CRSwNP. However, CRSwNP patients reported significantly less symptom control, compared to CRSsNP, in association with nasal and emotional symptoms.

The study concluded through its findings that CRSwNP and CRSsNP have differences in symptom profile, the effect on health-related QOL, and patient-perceived symptom control.