Chronic spontaneous urticaria is well-described in adults, but less so in children. The aim of this study was to describe the demographics, clinical characteristics, comorbidities, and outcomes of children with chronic, spontaneous urticaria.

Records of 380 children coded to have chronic urticaria were reviewed, of which 65.8% fulfilled the diagnostic criteria for chronic spontaneous urticaria. The average duration of chronic spontaneous urticaria was 12.25±15.2 months. The urticaria in 83.2% children resolved within 24 months. Thirty-four percent of patients had at least one atopic disease. Atopic comorbidities included atopic dermatitis in 17.2%, allergic rhinitis in 16%, asthma in 13.2% and food allergy in 3.2%. seven percent of patients had a concomitant autoimmune disease. And 3.6% had thyroid disease.

Chronic spontaneous urticaria in children is a self-limited disease with favorable prognosis. Atopic diseases are more prevalent in children with chronic spontaneous urticaria than in the general pediatric population; increasing the possibility of a special subgroup of TH2-related chronic urticaria in children.