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Circulating tumor cell status monitors the treatment responses in breast cancer patients: a meta-analysis.

Circulating tumor cell status monitors the treatment responses in breast cancer patients: a meta-analysis.
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Yan WT, Cui X, Chen Q, Li YF, Cui YH, Wang Y, Jiang J,


Yan WT, Cui X, Chen Q, Li YF, Cui YH, Wang Y, Jiang J, (click to view)

Yan WT, Cui X, Chen Q, Li YF, Cui YH, Wang Y, Jiang J,

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Scientific reports 2017 03 247() 43464 doi 10.1038/srep43464
Abstract

Whether circulating tumor cells (CTCs) can be used as an indicator of treatment response in breast cancer (BC) needs to be clarified. We addressed this issue by a meta-analysis. PubMed, EMBase and Cochrane library databases were searched in June 2016. Effect measures were estimated as pooled risk ratio (RR), odds ratio (OR) or mean difference by fixed- or random-effect models, according to heterogeneity of included studies. In total, 50 studies with 6712 patients were recruited. Overall analysis showed that there was a significant reduction of CTC-positive rate (RR = 0.68, 95% CI: 0.61-0.76, P < 0.00001) after treatment. Subgroup analyses revealed that neoadjuvant treatment, adjuvant treatment, metastatic treatment or combination therapy could reduce the CTC-positive rate, but surgery could not; moreover, the reduction was only found in HER2+ or HER2- patients but not in the triple-negative ones. Reduction of CTC-positive rate was associated with lower probability of disease progression (OR = 0.54, 95% CI: 0.33-0.89, P = 0.01) and longer overall survival period (mean difference = 11.61 months, 95% CI: 8.63-14.59, P < 0.00001) as well as longer progression-free survival period (mean difference = 5.07 months, 95% CI: 2.70-7.44, P < 0.0001). These results demonstrate that CTC status can serve as an indicator to monitor the effectiveness of treatments and guide subsequent therapies in BC.

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