For a study, researchers sought to describe the short-term clinical course and outcome of individuals who acquired asparaginase-associated pancreatitis (AAP) at a quaternary pediatric hospital. Clinical data from the medical records of patients with AAP were extracted, including laboratory results, inpatient and intensive care unit (ICU) days, imaging findings, the presence of complications such as the need for ventilation, dialysis, or the development of pleural effusions, and the mode of nutrition. The severity of the episode was classified using pediatric standards based on the development of organ failure and local consequences, including pancreatic necrosis. Between 2005 and 2015, 34 people were diagnosed with AAP, with 43 different episodes of pancreatitis. The average length of stay in the hospital was 10 days (range 2–65). About 7  occurrences (16.3%) necessitated treatment in the intensive care unit (ICU). In the 17  (39.5%) of the incidents were classified as severe due to the development of organ failure or the presence of pancreatic necrosis. In 17 cases (39.5%), total parenteral nutrition (TPN) was employed; in 34 episodes (79.1%), patients were discharged totally on oral feeds. In 20 incidents, antibiotics were given (46.5%). In 12 episodes, pancreatic necrosis was discovered during the first week (27.9%). AAP did not cause any deaths. The clinical history of AAP patients differs significantly. Moreover, in the study, a third of the patients had severe pancreatitis. Although AAP has a generally fair prognosis, many patients suffer systemic problems requiring TPN or ICU care.