Photo Credit: Strelciuc

The following is a summary of “Effective Skin Rejuvenation by a Novel Antioxidant Biostimulating Treatment,” published in the April 2025 issue of Journal of Cosmetic Dermatology by Iglesia et al. 

Facial skin aging had been a cumulative result of intrinsic and extrinsic stressors, with chemical peels serving as common noninvasive rejuvenation procedures, yet innovation in this area had remained limited, presenting an opportunity for next-generation technology.  

Researchers conducted a retrospective study to analyze the controlled delivery of antioxidant biostimulating acidic phytocompounds (ABAP) through a typical alpha-hydroxy acid (AHA)/ beta-hydroxy acid (BHA) chemical peel vehicle for skin rejuvenation.  

They tested the antioxidant biostimulating treatment (ABT) in both ex vivo and in vivo settings to explore its mechanism of action. The study involved 32 female subjects aged 38–60 years with Fitzpatrick skin types I–V and aimed to determine the efficacy and safety of ABT in these participants.  

The results showed that the ABT increased elastin and collagen by more than 25% after superficial skin wounding compared to untreated or vehicle controls. Expert clinical evaluation indicated that the ABT significantly improved fine lines, wrinkles, tactile laxity, and overall appearance following 3 ABT sessions. Clinical photography revealed enhancements in fine lines, wrinkles, skin smoothness, laxity, radiance, and OA appearance. 

Investigators concluded that the ABT, developed using ABAP technology, effectively improved facial skin aging for rejuvenation and was safe for individuals across all skin tones. 

Source: onlinelibrary.wiley.com/doi/10.1111/jocd.70196