Background Robotic pelvic surgery is increasingly utilized for reconstruction proximal to the genitourinary diaphragm. We describe a combined robotic transabdominal and open transperineal approach for complex anastomotic posterior urethroplasty. Methods We performed a multi-institutional retrospective study of patients who underwent anastomotic posterior urethroplasty by a combined robotic transabdominal and open transperineal approach between 1/2012 and 12/2018. Patient demographics; preoperative, intraoperative, and postoperative clinical data; and complications were reviewed. Urethroplasty success, de novo stress urinary incontinence (SUI), and de novo erectile dysfunction (ED) were evaluated. Results 12 patients were identified with a mean follow-up of 596 (range 73-1618) days. Mean patient age was 65.9 (range 53.4-76.8). Reconstruction required corporal splitting, prostatectomy, and gracilis muscle flap use in 1 (8.3%), 8 (66.7%), and 4 (33.3%) patients, respectively. Postoperative urinary leak, thromboembolic event, and wound abscess occurred in 1 (8.3%), 1 (8.3%), and 2 (16.7%) patients, respectively. Stenosis recurrence occurred in 2 patients (16.7%) at a mean 187.5 (20-355) postoperative days. De novo ED and de novo SUI were reported in 2 (16.7%) and 4 (33.3%) patients, respectively. Nine patients (75.0%) underwent placement of an artificial urinary sphincter at a mean interval of 359.2 (111-1456) days after the index procedure with no subsequent erosion. Conclusions Complex posterior urethroplasty by a combined robotic transabdominal and open transperineal approach is associated with success and complications rates comparable to open techniques and may allow for adjunctive procedures such as prostatectomy. This technique allows for reconstruction of posterior urethral stenoses that would otherwise have been managed conservatively or with urinary diversion.