Target Audience (click to view)
This activity is designed to meet the needs of physicians.
Learning Objectives(click to view)
Upon completion of the educational activity, participants should be able to:
- Identify the recommendations made in the Centers for Disease Control and Prevention 2014 clinical practice guideline on pre-exposure prophylaxis for the prevention of HIV infection in the United States;
- Integrate these recommendations into the care of their patients who are at high risk of acquiring HIV infection.
Method of Participation(click to view)
Statements of credit will be awarded based on the participant reviewing monograph, correctly answer 2 out of 3 questions on the post test, completing and submitting an activity evaluation. A statement of credit will be available upon completion of an online evaluation/claimed credit form at www.akhcme.com/pwapril5. You must participate in the entire activity to receive credit. If you have questions about this CME/CE activity, please contact AKH Inc. at firstname.lastname@example.org.
Credit Available(click to view)
CME Credit Provided by AKH Inc., Advancing Knowledge in Healthcare
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of AKH Inc., Advancing Knowledge in Healthcare and Physician’s Weekly’s. AKH Inc., Advancing Knowledge in Healthcare is accredited by the ACCME to provide continuing medical education for physicians.
AKH Inc., Advancing Knowledge in Healthcare designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Commercial Support(click to view)
There is no commercial support for this activity.
Disclosures(click to view)
It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with commercial interests whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are resolved by AKH prior to accreditation of the activity and may include any of or combination of the following: attestation to non-commercial content; notification of independent and certified CME/CE expectations; referral to National Author Initiative training; restriction of topic area or content; restriction to discussion of science only; amendment of content to eliminate discussion of device or technique; use of other author for discussion of recommendations; independent review against criteria ensuring evidence support recommendation; moderator review; and peer review.
Disclosure of Unlabeled Use & Investigational Product(click to view)
This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Disclaimer(click to view)
This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant’s misunderstanding of the content.
Faculty & Credentials(click to view)
Christopher Cole- Senior Editor
Discloses no financial relationships with pharmaceutical or medical product manufacturers.
Dorothy Caputo, MA, BSN, RN- CE Director of Accreditation
Discloses no financial relationships with pharmaceutical or medical product manufacturers.
AKH planners and reviewers have no relevant financial relationships to disclose.
Take CME(click to view)
Since the early days of the HIV epidemic in the United States, clinicians have made continued efforts to educate people on behaviors that could significantly reduce their risk of acquiring HIV infection. However, over the last 10 to 15 years, the rate of new infections in the U.S. has remained steady at about 50,000 per year. Recently, pre-exposure prophylaxis (PrEP)—daily doses of two specific antiretroviral medications to uninfected patients at high-risk of HIV infection—has been shown to be safe and effective to prevent HIV acquisition. “Despite our best efforts, we haven’t seen declines in annual HIV infection rates,” says Dawn K. Smith, MD, MS, MPH. The CDC recently released guidelines on PrEP to provide clinicians the information they need to use this prevention strategy and help drive down the rate of new HIV infections.
Published in the Morbidity and Mortality Weekly Report, the CDC guidelines report that taking PrEP regularly provides substantial protection against HIV acquisition in multiple populations. The guidelines offer recommendations on indications for prescribing PrEP medication. PrEP is recommended for HIV-uninfected patients who:
♦ Are in an ongoing sexual relationship with an HIV-infected partner.
♦ Are gay or bisexual men who have had sex without condoms or have been diagnosed with a sexually transmitted infection within the past 6 months, and are not in a mutually monogamous relationship with a partner who recently tested HIV-negative.
♦ Are heterosexual and do not always use condoms when having sex with partners known to be at risk for HIV (eg, injection drug users or bisexual men of unknown HIV status), and are not in a mutually monogamous relationship with a partner who recently tested HIV-negative.
♦ Have injected illicit drugs and shared equipment or been in a treatment program for injection drug use in the past 6 months.
Because the success of PrEP lies heavily on patients taking their medications as prescribed, the guidelines place an emphasis on the importance of adhering to the daily regimen (Table 1). “When providers prescribe PrEP, they should be clear with patients about why they need to take their medication on a daily basis,” Dr. Smith says. “Daily use is the only way to achieve substantial protection from HIV. It’s also important to understand that patients may have different barriers to maintaining medication adherence. We then must help patients overcome those barriers with help from commonly available tools and strategies. Patients should also know what to expect when taking PrEP, including the potential for side effects and how long they may last.”
Keys to Success
According to Dr. Smith, many patients who could benefit from PrEP do not share information on their sexual behaviors with providers because they are afraid of how they will be perceived. “We encourage providers, particularly those in communities with high rates of HIV infection, to be proactive in helping their patients avoid infection,” she says. “That includes taking a better sexual history and demonstrating an openness to discuss issues like whether they’ve had a sexually transmitted infection or who they’ve had sex with in the past. The key is to do this in a non-judgmental manner.” The guidelines recommend informing candidates for PrEP about the goals of using this prevention method (Table 2).
Anecdotal evidence also suggests that some patients visit healthcare providers who are unfamiliar with PrEP, are unwilling to provide antiretrovirals to HIV-negative patients, or are unaware that PrEP has been beneficial in multiple populations at risk. “We hope the guidelines increase awareness among providers that there are multiple situations in which PrEP may benefit patients,” says Dr. Smith. “PrEP should be offered in some cases, and we need to improve use of these guidelines.”
Dr. Smith notes that providers practicing at sexually transmitted disease clinics or in hospitals often see patients who are appropriate for PrEP but feel they should not offer it because they often do not provide continuous care. “In order to protect more high-risk patients, we need to develop models for linking these individuals to the appropriate care systems,” she says. “That may mean partnering with primary care providers who are willing and able to provide PrEP at their clinics. More research is needed on the delivery of health services to understand how we can improve the use of PrEP and make it available to populations that would benefit most.”
Dr. Smith encourages providers to refer to the CDC guidelines to fully understand the promise of PrEP and ensure that the treatment is provided to the most appropriate candidates. For those looking for additional advice or information, the CDC has established PrEPline, a dedicated toll-free clinicians’ consultation service that can be reached at 855-448-7737 or by visiting http://nccc.ucsf.edu/clinical-resources/pep-resources/prep.
Readings & Resources (click to view)
Centers for Disease Control and Prevention (CDC). Pre-exposure prophylaxis for the prevention of HIV infection in the United States: 2014 clinical practice guideline. Available at: http://www.cdc.gov/hiv/pdf/guidelines/PrEPguidelines2014.pdf.
Centers for Disease Control and Prevention (CDC). Pre-exposure prophylaxis for the prevention of HIV infection in the United States: 2014 clinical providers’ supplement. Available at: http://www.cdc.gov/hiv/pdf/PrEPProviderSupplement2014.pdf.
US Preventive Services Task Force. Screening for HIV: current recommendations. U.S. Preventive Services Task Force. 2013. Available at: http://www.uspreventiveservicestaskforce.org/uspstf/uspshivi.htm.
Centers for Disease Control and Prevention (CDC). Update to interim guidance for preexposure prophylaxis (PrEP) for the prevention of HIV infection: PrEP for injecting drug users. MMWR Morb Mortal Wkly Rep. 2013;62:463-465.
Centers for Disease Control and Prevention (CDC). Interim guidance: preexposure prophylaxis for the prevention of HIV infection in men who have sex with men. MMWR Morb Mortal Wkly Rep. 2011;60:65-68.
Centers for Disease Control and Prevention (CDC). Interim guidance for clinicians considering the use of preexposure prophylaxis for the prevention of HIV infection in heterosexually active adults. MMWR Morb Mortal Wkly Rep. 2012;61:586-590.