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Co-targeting BCL-X and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice.

Jan 02, 2023

ABOUT THE CONTRIBUTORS

  • Sajid Khan

    Department of Biochemistry & Structural Biology, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. khans10@uthscsa.edu.

    Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. khans10@uthscsa.edu.

    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA. khans10@uthscsa.edu.

    Patrick Kellish

    Department of Anatomy & Cell Biology, College of Medicine, University of Florida, Gainesville, FL, USA.

    Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.

    Nick Connis

    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

    Dinesh Thummuri

    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

    Janet Wiegand

    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

    Peiyi Zhang

    Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.

    Xuan Zhang

    Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.

    Vivekananda Budamagunta

    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

    Genetics and Genomics Graduate Program, Genetics Institute, College of Medicine, University of Florida, Gainesville, FL, USA.

    Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.

    Nan Hua

    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

    Yang Yang

    Department of Biochemistry & Structural Biology, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

    Umasankar De

    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.

    Lingtao Jin

    Department of Molecular Medicine, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

    Weizhou Zhang

    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.

    Guangrong Zheng

    Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.

    Robert Hromas

    Department of Medicine, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

    Christine Hann

    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

    Maria Zajac-Kaye

    Department of Anatomy & Cell Biology, College of Medicine, University of Florida, Gainesville, FL, USA.

    Frederic J Kaye

    Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.

    Daohong Zhou

    Department of Biochemistry & Structural Biology, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

    Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

REFERENCES & ADDITIONAL READING

PubMed

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