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Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension.

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension.
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Kajikawa M, Maruhashi T, Hidaka T, Nakano Y, Kurisu S, Matsumoto T, Iwamoto Y, Kishimoto S, Matsui S, Aibara Y, Yusoff FM, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Watanabe T, Tone H, Hibi M, Osaki N, Katsuragi Y, Higashi Y,


Kajikawa M, Maruhashi T, Hidaka T, Nakano Y, Kurisu S, Matsumoto T, Iwamoto Y, Kishimoto S, Matsui S, Aibara Y, Yusoff FM, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Watanabe T, Tone H, Hibi M, Osaki N, Katsuragi Y, Higashi Y, (click to view)

Kajikawa M, Maruhashi T, Hidaka T, Nakano Y, Kurisu S, Matsumoto T, Iwamoto Y, Kishimoto S, Matsui S, Aibara Y, Yusoff FM, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Watanabe T, Tone H, Hibi M, Osaki N, Katsuragi Y, Higashi Y,

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European journal of nutrition 2018 01 12() doi 10.1007/s00394-018-1611-7
Abstract
PURPOSE
The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction.

METHODS
This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake.

RESULTS
Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels.

CONCLUSIONS
These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction.

CLINICAL TRIAL REGISTRATION
URL for Clinical Trial: https://upload.umin.ac.jp ; Registration Number for Clinical Trial: UMIN000013283.

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