Cognitive fatigability (CF) can be defined as an inability to maintain an optimal level of performance throughout a sustained cognitive task. It remains unclear, however, whether there is a specific moment during a cognitive task, such as the Paced Auditory Serial Addition Test (PASAT), when performance begins to break down. Thus, the present study aimed to evaluate how performance declines over time on the PASAT in people with multiple sclerosis (PwMS) compared to healthy controls.
178 PwMS and 186 control participants were administered the 3″ and 2″ PASAT as part of a larger battery of neuropsychological tests. To examine how CF differed between the groups, repeated measures ANOVAs were used to evaluate the cumulative error rates made by each group throughout the task. In addition, how the error rate developed across the task on each trial was examined to evaluate in more detail the difference between groups with respect to how performance declined from the beginning to the end of the task. Lastly, exploratory two-way independent sample ANOVAs examined whether there was an influence of stimulus complexity (single vs. double-digit answers) on task performance.
Compared to healthy controls, PwMS produced a greater number of errors overall on the PASAT and demonstrated more vulnerability to CF than healthy controls, as reflected by a greater number of errors made towards the end of the task. This difference was more noticeable on the 3″ PASAT, given the difficulty both groups experienced on the 2″ form. On the 3″ PASAT, by Trial 37, PwMS had made significantly more cumulative errors than controls, however the rate of error generation was largely consistent and linear from the beginning to the end. Some of the group differences observed may be partially attributable to stimulus complexity influencing task performance.
The 3″ PASAT is more sensitive to group differences in CF and error generation than the 2″ PASAT. With respect to CF, the greater vulnerability observed in the MS group is not due to a breakdown in performance or an increase in the rate of error generation at any specific point during the task; rather there is a linear decline in performance from the start. These results suggest that PwMS struggle to maintain optimal performance during sustained cognitive effort from the very beginning and demonstrate a steeper, but steady, rate of decline over time.

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