Reconstruction of damaged nerves remains a significant unmet challenge in clinical medicine. Topographical and mechanical stimulations play important roles to repair peripheral nerve injury. The synergistic effects of topography and mechanical rigidity may significantly accelerate nerve regeneration. In this work, we developed a nerve-guiding collagen/polylactic acid (PLA) electrospun scaffold to facilitate peripheral nerve repair. The obtained anisotropic PLA electrospun scaffolds simulated the directional arranged structure of nerve realistically and promoted axonal regeneration after sciatic nerve injury when compared with the isotropic PLA electrospun scaffolds. Moreover, the collagen-modified PLA electrospun scaffolds further provided sufficient mechanical support and favorable microenvironment for axon regeneration. In addition, we observed that collagen-modified PLA electrospun scaffolds facilitated the axon regeneration by regulating YAP molecular pathway. Taken together, we engineered collagen-modified anisotropic PLA electrospun scaffolds may be a potential candidate to combine topography and mechanical rigidity for peripheral nerve regeneration. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
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