For a study, it was determined that in pregnancy, gut bacteria played a role in glucose metabolism regulation. Collinsella abundance was positively linked with circulating insulin; nevertheless, it was unknown what factors influence Collinsella abundance. The research was to confirm the link between Collinsella and insulin, as well as to determine whether macronutrient consumption affects Collinsella abundance and gut microbiota makeup. At 16 weeks gestation, the gut microbiota profiles of 57 overweight and 73 obese pregnant women from the SPRING (Study of PRobiotics IN Gestational diabetes) experiment were examined by 16S rRNA sequencing and linked with metabolic hormone levels and macronutrient intake. Network analysis was used to assess the gut microbiota composition in the top and bottom 10% of dietary fiber intake. In this group, Collinsella abundance was positively connected with circulating insulin (rho=0.30, P=0.0006), irrespective of maternal BMI, but inversely correlated with dietary fiber intake (rho=-0.20, P=0.025). Low dietary fiber intake was linked to a gut microbiota that favors lactate fermentation, whereas high fiber intake encourages bacteria that produce short-chain fatty acids. Insufficient nutritional fiber may promote Collinsella overgrowth and change the gut microbiota’s general fermentation pattern. This shows that dietary choices made during pregnancy can alter the gut microbiota’s healthy ecology, potentially affecting the host’s metabolic and inflammatory health.
Link:www.tandfonline.com/doi/full/10.1080/19490976.2017.1406584#
