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Colonization Resistance: The Deconvolution of a Complex Trait.

Colonization Resistance: The Deconvolution of a Complex Trait.
Author Information (click to view)

Olsan EE, Byndloss MX, Faber F, Rivera-Chavez F, Tsolis RM, Baumler AJ,


Olsan EE, Byndloss MX, Faber F, Rivera-Chavez F, Tsolis RM, Baumler AJ, (click to view)

Olsan EE, Byndloss MX, Faber F, Rivera-Chavez F, Tsolis RM, Baumler AJ,

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The Journal of biological chemistry 2017 04 07() pii jbc.R116.752295
Abstract

Carbapenemase-producing Enterobacteriaceae are an emerging threat to hospitals worldwide and antibiotic exposure is a risk factor for developing fecal carriage that may lead to nosocomial infection. Here we review how antibiotics reduce colonization resistance against Enterobacteriaceae to pinpoint possible control points for curbing their spread. Recent work identifies host-derived respiratory electron acceptors as a critical resource driving a post-antibiotic expansion of Enterobacteriaceae within the large bowel. By providing a conceptual framework for colonization resistance against Enterobacteriaceae, these mechanistic insights point to the metabolism of epithelial cells as a possible target for intervention strategies.

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