The aim of this research is To address the prognostic value of combining tubular basement membrane (TBM) and glomerular basement membrane (GBM) thickness in diabetic nephropathy (DN).

This retrospective study enrolled 110 patients with type 2 diabetes and biopsy-proven DN from 2011 to 2018. The pathological findings were confirmed according to the Renal Pathology Society classifications. GBM and TBM thicknesses were determined using the Haas’ direct measurement/arithmetic mean method and orthogonal intercept method, respectively. Cox proportional hazard models were used to investigate the hazard ratios (HRs) for the influence of combined GBM and TBM thickness for predicting end-stage renal disease (ESRD).

Patients were assigned to three groups according to the median GBM and TBM thickness: GBMloTBMlo (GBM < 681 nm and TBM < 1200 nm), GBMhiTBMlo/GBMloTBMhi (GBM ≥ 681 nm and TBM < 1200 nm, or GBM < 681 nm.

Reference link-