The management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma.
The study was done to assess the independent effect of different comorbidities on clinical, functional, and biologic features of SA. 72 patients with SA according to GINA guidelines were examined.
The mean age of the patients was 59.1 years. Comorbidities with higher prevalence were: CRSwNP or CRSsNP, obesity, and GERD, with some overlapping among them. In a univariate analysis comparing patients with single comorbidities with the other ones, asthmatics with CRSwNP had lower lung function and higher sputum eosinophilia; obese asthmatics had worse asthma control and quality of life, and tended to have lower sputum eosinophils; asthmatics with GERD showed the worse quality of life. In multivariate analysis, obesity was the only independent factor associated with poor asthma control, while CRSwNP was the only independent factor associated with airway eosinophilia. Lower lung function was associated with the male gender and showed a trend for the association with nasal polyps.
The study concluded through its findings that coexisting comorbidities are associated with different features of SA.
Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-018-0103-x
