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Comparative susceptibility of rhesus macaques of Indian and Chinese origin to vaginal SHIV transmission as models for HIV prevention research.

Comparative susceptibility of rhesus macaques of Indian and Chinese origin to vaginal SHIV transmission as models for HIV prevention research.
Author Information (click to view)

Veazey R, Ling B,


Veazey R, Ling B, (click to view)

Veazey R, Ling B,

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AIDS research and human retroviruses 2017 08 10() doi 10.1089/AID.2017.0173

Abstract

Historically, Indian origin rhesus macaques (iRM) have been preferred for SIV/HIV prevention, pathogenesis, and treatment studies, yet their supply is limited. Chinese origin rhesus macaques (cRM) are currently more available yet little is known regarding the relative susceptibility of this subspecies to vaginal transmission of SIV or SHIV. Here we compared the susceptibility of 40 cRM and 21 iRM to a single vaginal challenge with SHIVsf162P. Our results showed cRM have comparable primary SHIV infection as iRM, underscoring their equal importance in studies of HIV transmission and prevention.

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