Advertisement

 

 

Comparative Susceptibility of Rhesus Macaques of Indian and Chinese Origin to Vaginal Simian-Human Immunodeficiency Virus Transmission as Models for HIV Prevention Research.

Comparative Susceptibility of Rhesus Macaques of Indian and Chinese Origin to Vaginal Simian-Human Immunodeficiency Virus Transmission as Models for HIV Prevention Research.
Author Information (click to view)

Veazey RS, Ling B,


Veazey RS, Ling B, (click to view)

Veazey RS, Ling B,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

AIDS research and human retroviruses 2017 11 07() doi 10.1089/AID.2017.0173

Abstract

Historically, Indian rhesus macaques (iRMs) have been preferred for simian immunodeficiency virus (SIV)/HIV prevention, pathogenesis, and treatment studies, yet their supply is limited. Chinese rhesus macaques (cRMs) are currently more available, yet little is known regarding the relative susceptibility of this subspecies to vaginal transmission of SIV or simian-human immunodeficiency virus (SHIV). In this study, we compared the susceptibility of 40 cRMs and 21 iRMs with a single vaginal challenge with SHIVsf162P. Our results showed that cRMs have comparable primary SHIV infection as iRMs, underscoring their equal importance in studies of HIV transmission and prevention.

Submit a Comment

Your email address will not be published. Required fields are marked *

five × four =

[ HIDE/SHOW ]