Observational case series.
A total of 82 subjects(82 eyes) showing DH who had undergone more than five reliable spectral-domain optical coherence tomography(OCT) tests were included. BMO-MRW and RNFL were measured with OCT at 3-month intervals. The rates of change in global and each Garway-Heath sector were calculated with a linear mixed-effects model after adjusting for age, sex, and BMO area.
The mean follow-up period was 21.57±7.88 months with a mean number of 7.88±2.39 OCT tests. Baseline demographics were age,58.37±10.65 years; 46.3% females; and mean deviation, -4.41±5.04dB. The global rate of change in BMO-MRW was -3.507±0.675 μm/yr and in RNFL was -1.404±0.208 μm/yr. The rate of change was the greatest in the inferotemporal sector, which was -9.141±1.254 μm/yr in BMO-MRW and -4.204±0.490 μm/yr in the RNFL. The rate of change was significantly greater in BMO-MRW than in the RNFL in all sectors except for the nasal sector(P < 0.05). Percent reduction was significantly greater in BMO-MRW than in RNFL in the inferotemporal and superotemporal sectors(P < 0.05).
BMO-MRW showed a significantly greater rate of change than did RNFL in eyes showing DH, especially in the inferotemporal and superotemporal sectors in percent reduction. Thus, it may be more advantageous to detect glaucomatous progression earlier in BMO-MRW than in the RNFL in eyes showing DH that are more likely to progress.
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