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Compensatory lung growth after bilobectomy in emphysematous rats.

Compensatory lung growth after bilobectomy in emphysematous rats.
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Almeida FM, Saraiva-Romanholo BM, Vieira RP, Moriya HT, Ligeiro-de-Oliveira AP, Lopes FD, Castro-Faria-Neto HC, Mauad T, Martins MA, Pazetti R,


Almeida FM, Saraiva-Romanholo BM, Vieira RP, Moriya HT, Ligeiro-de-Oliveira AP, Lopes FD, Castro-Faria-Neto HC, Mauad T, Martins MA, Pazetti R, (click to view)

Almeida FM, Saraiva-Romanholo BM, Vieira RP, Moriya HT, Ligeiro-de-Oliveira AP, Lopes FD, Castro-Faria-Neto HC, Mauad T, Martins MA, Pazetti R,

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PloS one 2017 07 2712(7) e0181819 doi 10.1371/journal.pone.0181819
Abstract

Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respiratory mechanics and quality of life for the patients. An animal model of elastase-induced pulmonary emphysema was used to investigate the structural and functional lung response after LVRS. Bilobectomy was performed six weeks after elastase instillation. Two weeks after bilobectomy, CLG effects were evaluated by lung mechanics and histomorphometric analysis. After bilobectomy, the emphysematous animals presented decreased mean linear intercepts, increased elastic fiber proportion, and increased alveolar surface density, total volumes of airspace, tissue and respiratory region and absolute surface area. We conclude that bilobectomy promoted CLG in emphysematous animals, resulting in alveolar architecture repair.

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