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Complete Genome Sequences of Human Immunodeficiency Type 1 Viruses Genetically Engineered To Be Tropic for Rhesus Macaques.

Complete Genome Sequences of Human Immunodeficiency Type 1 Viruses Genetically Engineered To Be Tropic for Rhesus Macaques.
Author Information (click to view)

Nomaguchi M, Doi N, Koma T, Adachi A,


Nomaguchi M, Doi N, Koma T, Adachi A, (click to view)

Nomaguchi M, Doi N, Koma T, Adachi A,

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Genome announcements 2017 09 285(39) pii 10.1128/genomeA.01063-17

Abstract

We have constructed two human immunodeficiency type 1 (HIV-1) derivatives, CXCR4 tropic and CCR5 tropic, that replicate in rhesus macaques. They are genetically engineered to be resistant to macaque restriction factors against HIV-1, including TRIM5α, APOBEC3, and tetherin proteins. The two HIV-1 variants described here are fundamental clones aiming for rhesus infection studies of HIV-1.

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