For a study, the researchers examined the oncological outcomes of complicated segmentectomy and wedge resection for clinical stage 0-IA lung cancer using propensity score-matched analysis on a large cohort, multicenter database. They performed a retrospective analysis of data from 506 patients with clinical stage 0-IA, solid component size less than or equal to  2.0 cm, who underwent surgical resection at three institutions between 2010 and 2018. All patients and their propensity score-matched pairs had their surgical outcomes following complex segmentectomy (n=222), and “location-adjusted” wedge resection (n=284) was examined. 5 year cancer-specific survival rate, 97.4% vs 93.7%; P=.065; and 5 year recurrence-free interval [RFI] rates, 96.9% vs. 86.15%; P=.0005). This pattern was also observed in subanalyses of solid tumors alone. In 179 propensity score-matched pairs, the prognosis of complex segmentectomy patients tended to be better than that of wedge resection patients (5-year cancer-specific survival rates, 96.8% vs. 92.9%; 5-year RFI rates, 96.3% vs. 87.5%). Complex segmentectomy significantly reduced lung cancer recurrence compared to wedge resection (hazard ratio, 0.32; 95% CI, 0.12-0.73; P=.0061; multivariable Cox regression analysis for RFI). When compared to wedge resection, complex segmentectomy could yield superior oncological outcomes.

Source – clinical-lung-cancer.com/article/S1525-7304(21)00267-9/fulltext